DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and met-1

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_491340.2	Gene:	met-1 / 172026	WormBaseID:	WBGene00016603	Length:	1604	Species:	Caenorhabditis elegans

Alignment Length:	1205	Identity:	213/1205 - (17%)
Similarity:	366/1205 - (30%)	Gaps:	433/1205 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 KNTPESGEDANKAAAKEPSGTPVAASSEATVPAPGSASSSNSPLPGTPPKYSNPHNLTIGARLEA 223
            |...|..:...|.||....|..| ..::|..|||  .:.:.....|.|||.....|     .|..
Worm    10 KKRTEMVQTRRKTAAAVQDGGAV-KENKAKPPAP--QTPTKRAKRGRPPKIKTDAN-----TLNT 66

  Fly   224 LSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSNRVLPVF 288
            .|...|.:..:::..:|::.::|.            :.:.||.|....:.|.     |:.:||
Worm    67 PSTSSNLVDDKLLIESESQDSILT------------NEADSFLEKEVEEIED-----SSDILP-- 112

  Fly   289 ELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDD---GYVKNVRAVHMNKMPKQLPPVQVA--- 347
                   .:.:.|.| |..:.|...:...:|..|:   ....|:....:.:...|:.|...|
Worm   113 -------DKINSPEK-PSVLVKRRSSTRLKVKTDEDEKDVPVNIEVAVLEEKSIQIEPTSPAHPE 169

  Fly   348 EEGASKSPTPV----------GTPVSSA----------------PVAPKRASTGS----LGGSSG 382
            :...|.|..|:          ..|.|||                |:..|.||..|    :..|..
Worm   170 DPQPSTSSLPLVEPIEDIVEPNEPTSSADPPVSNIKDEDIKEEEPLIKKPASDESESMDIANSES 234

  Fly   383 SSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIP-----HDGEWTCHWVNDQPIGTEGFLIVGE 442
            .:.|..|:..|:          ::...|:.||:.|     ..||  .|...||....:.    ||
Worm   235 GNDSDSSEADPR----------TIPSFSIPLPDTPPPNFAKRGE--IHVDVDQKNSKQS----GE 283

  Fly   443 HQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNPDVY 507
            .|.|                          |:         |.|.||       :.|.:.:|.:.
Worm   284 SQSP--------------------------WE---------RAREKS-------ASNPLSSPTMS 306

  Fly   508 DFSIHRRRAKDINAYVYTH---------GYNPQPPPKPRPMDV---------------------- 541
            ...||           :.|         ..:|.|||.|.|...
Worm   307 RPRIH-----------FLHPAYQSFTNDSVSPLPPPPPEPAPAREKVENGGPTTFKMTFKKAANI 360

  Fly   542 ------------------SMNSTLDQS-ITSQHSLPSTPMPVKESQYMEAPVASLMPPAEL---- 583
                              |::|::..| :.|..|:.|...|.|.|...:...::.:||.::
Worm   361 PILKTSAFEQPSSPPPSSSVSSSISLSEVNSSTSIASESSPAKRSSNFDLTASNELPPPQMVELP 425

  Fly   584 ------MSPQTQPADETKPKIEAE---ILEASEGGT---SQLMLADPHVVENGFAFIGGLKVKIQ 636
                  |.|..:.|::.......|   :|.:....|   ..|.|..|...:...:.|..|||..:
Worm   426 KLSFFNMPPAVRSAEDDSAMTSEEPILLLRSPNSATPDDDALFLTTPPPPKMTESEIQALKVATE 490

  Fly   637 D-NLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSID----QVEA 696
            . |..:..|||..|..|            |:|..:........::...::|.....|    |.|.
Worm   491 KVNQVIARREDSEKDVR------------HREDRDDYDRRRDDRDRRSRKTDSERNDQRGRQRED 543

  Fly   697 VPKNQIPNQQFFAKMHQQD-----LQQSRSFKRQSVSATATSSTPSD-----------ITPTKAL 745
            ..:.....::...|.|.::     ||:.:..:|:...........:|           ....|.:
Worm   544 DERRAREREREVTKRHDREREEMRLQKQKDEERRKKDEEERIQKENDEKKQKEDEAKMEEEKKKI 608

  Fly   746 LSPKMEPPSVSPTVESGI--------KQEDVSLD---AGPTQSFNPSLSRS------------CK 787
            ...:|:.|......||..        |.|.::.:   .|...|.|..::|:            ||
Worm   609 KEEEMKIPEFELISESKYLTRNANKKKTESLTCECHRTGGNCSDNTCVNRAMLTECPSSCQVKCK 673

  Fly   788 RARLSPSKRP------SGSRKSNRQRSQRRPILSDNPAGHGLTEQ--DVEETRQSFNTPTPDTRI 844
            ..|.:..|..      :|:.|....|:     :.|...|..:.|.  :|.| |..:.........
Worm   674 NQRFAKKKYAAVEAFHTGTAKGCGLRA-----VKDIKKGRFIIEYIGEVVE-RDDYEKRKTKYAA 732

  Fly   845 DSKKRRSGAATTPISSIDSPAMGDSVSTPSS--NDQTDINA-----ALAPPPAET-----LSKAP 897
            |.|.:......|.:.:||:...|:    ||.  |...|.||     ::...|.:.     .||
Worm   733 DKKHKHHYLCDTGVYTIDATVYGN----PSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSK-- 791

  Fly   898 QYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYI 962
            ::||. ||.|..    ..:.:|    ||.:      .:.|.|.. .:|:|             :|
Worm   792 RFIKA-GEEITF----DYQFVN----YGRD------AQQCFCGS-ASCSG-------------WI 827

  Fly   963 CRNPQRGRDSMRFKHDQDWLFEGKLPVAAYHTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLL 1027
            .:.|:      .|..|:|                      .:::...|
Worm   828 GQKPE------EFSSDED----------------------DDIVTTRH----------------- 847

  Fly  1028 VKINIARNRCHPKLYLWAKKWDEDNLDSTALTPVKRAKLEAPD-LPNVPQPEAAIDPEECQYRLI 1091
              ||:                ||:          :..|||..| |.|..:.|...|       ::
Worm   848 --INM----------------DEE----------EEEKLEGLDHLGNHERNEVIKD-------ML 877

  Fly  1092 EHIKVQQSLVLDRLNDIEAEM-DELEKEDTLDDLKDADISTT------KEALATFIKE------- 1142
            :.:.::......::..|.:.| |..::.|.:.::..:|.|.|      ||.:||.:.|
Worm   878 DDLVIRNKKHARKVITIASAMTDYSQRVDVIQEIFSSDTSVTVQKFYAKEGMATLMAEWLSEDDY 942

  Fly  1143 -LETMKRLAKL---------NQVANMKQTLRDSAT 1167
             |:.:|.:..:         :..|...:.||||.:
Worm   943 SLDNLKLVQAILKALHTELFDSCAKNDRLLRDSTS 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	6/39 (15%)
		MeCP2_MBD	449..522	CDD:238690	9/72 (13%)
		PHD_SF	919..963	CDD:304600	7/43 (16%)
met-1	NP_491340.2	PHA03283	<219..308	CDD:223032	27/146 (18%)
		AWS	637..682	CDD:197795	8/44 (18%)
		SET	694..810	CDD:214614	29/136 (21%)
		tolA_full	<1300..>1375	CDD:274303
		WW	1366..1393	CDD:238122
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030