DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and PHF13

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_011539064.1	Gene:	PHF13 / 148479	HGNCID:	22983	Length:	309	Species:	Homo sapiens

Alignment Length:	262	Identity:	59/262 - (22%)
Similarity:	92/262 - (35%)	Gaps:	71/262 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   748 PKMEPP---SVSPTVESGIKQEDVSLDAG----------PTQS-----FNPSLSRSCKRARLSPS 794
            ||.|.|   |.||...:....:....|||          |...     ..|:|.:..|.:.....
Human    54 PKEELPLRSSPSPANSTAGTIDSDGWDAGFSDIASSVPLPVSDRCFSHLQPTLLQRAKPSNFLLD 118

  Fly   795 KRPSGSRKSNRQRSQRRPILSDNPAGHGLTE--QDVEETRQSFNTPTPDTRIDSKKRRSGAATTP 857
            ::.:...|..::|.:|.   ||.|...|...  ..:|.......|||..|..|..:    |.:.|
Human   119 RKKTDKLKKKKKRKRRD---SDAPGKEGYRGGLLKLEAADPYVETPTSPTLQDIPQ----APSDP 176

  Fly   858 ISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQE------- 915
            .|..||       .||||..    .|.::|...:.       ||..|:. .|||..::
Human   177 CSGWDS-------DTPSSGS----CATVSPDQVKE-------IKTEGKR-TIVRQGKQVVFRDED 222

  Fly   916 -----------------EIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYIC 963
                             :::.|.|........||:|..|..|.|.:| ..:::::||:.:||..|
Human   223 STGNDEDIMVDSDDDSWDLVTCFCMKPFAGRPMIECNECHTWIHLSC-AKIRKSNVPEVFVCQKC 286

  Fly   964 RN 965
            |:
Human   287 RD 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600	13/43 (30%)
PHF13	XP_011539064.1	PHD_PHF13	241..287	CDD:277102	13/46 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900