DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and DIDO1

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_011526806.1	Gene:	DIDO1 / 11083	HGNCID:	2680	Length:	2276	Species:	Homo sapiens

Alignment Length:	1186	Identity:	219/1186 - (18%)
Similarity:	378/1186 - (31%)	Gaps:	389/1186 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 TPGNAQSSTNDDVIKATVDQIVAQILSESAERKATEEGK-TGKAADDVKNTPESGEDANKAAA-- 173
            :|.....||.:|  :.:.::..|.    :|.:|....|. .||........|:....||.|||
Human   559 SPSLLYKSTKED--RRSEEKAAAM----AASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATP 617

  Fly   174 ---KEPSG-------------TPVAASSEA--TVPAPGSASSSNSPLPGT---------PPKYSN 211
               |.|||             ||.:.:|.|  ..|||.:|::::...||:         |...|.
Human   618 AIKKPPSGFKGTIPKRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSV 682

  Fly   212 PHNLTIGARLEALSVEGNWLPARIVE-------------VNETEQTLLVRFERNH-KLKVSPSTS 262
            |.......||.|:|...:...::|.:             ||:::..::...|... .|.:.....
Human   683 PMASPAPGRLGAMSAAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMF 747

  Fly   263 GSFQEWMAIKSERLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVK 327
            ..||    :...|.:.:..:   .:|.|.:.         |..|...::|..:
Human   748 NLFQ----VTDNRYKSKYRS---IMFNLKDP---------KNQGLFHRVLREE------------ 784

  Fly   328 NVRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPV--------SSAPVAPKRASTGSLGGSSGSS 384
                :.:.|:.:..|...|::|.::....|..:.:        .|...||::.:...|..|...|
Human   785 ----ISLAKLVRLKPEELVSKELSTWKERPARSVMESRTKLHNESKKTAPRQEAIPDLEDSPPVS 845

  Fly   385 GSKK----SKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQK 445
            .|::    ::..|::...||||:.|..:.........|..:..|.....|....|.
Human   846 DSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSAED--------- 901

  Fly   446 PTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFR-----SKSDLKLFLESQNLVYNPD 505
                                             .|:.|:.:     .|.|||...:|......||
Human   902 ---------------------------------EPAPKKQKLSASVKKEDLKSKHDSSAPDPAPD 933

  Fly   506 VYDFSIHR---RRAKDINAYVYTH-----GYNPQPP----PKPRPMD------VSMNSTLDQSIT 552
            ..|..:..   ..|.:......:|     .|.|.||    |:|.|::      .|..|.:..::|
Human   934 SADEVMPEAVPEVASEPGLESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPCPASCGSGVVTTVT 998

  Fly   553 ------------------SQHSLPSTPMPVKESQYMEAPVAS--LMPPAELMSPQTQP-----AD 592
                              |..|.|.:...|:..|.:..||.:  ::|.:.|..|.:.|     :.
Human   999 VSGRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAKPSSSPDPRYLSV 1063

  Fly   593 ETKPKIEAEILEASEGGTSQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFL 657
            ...|.|......:...|.:.|.|:....:..||..:..: .|.....|  |...|. .|..||..
Human  1064 PPSPNISTSESRSPPEGDTTLFLSRLSTIWKGFINMQSV-AKFVTKAY--PVSGCF-DYLSEDLP 1124

  Fly   658 -LIHI--RHYHKEFAEHVSHCPK--MQELAVKRTHPSSIDQVEAVPKNQIPNQQFFA-------- 709
             .|||  |...|...::|.....  .:||.:.|.||::.::..|    .|....:|:
Human  1125 DTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVA----YISLYSYFSSRGRFGVV 1185

  Fly   710 ---KMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESG------IKQ 765
               ..|.:||        ..:..:|....||.:.|.:   .|.:|.|  .|.:..|      ||:
Human  1186 ANNNRHVKDL--------YLIPLSAQDPVPSKLLPFE---GPGLESP--RPNIILGLVICQKIKR 1237

  Fly   766 EDVSLDAGPTQSFNPSLSRSCKRARLSPSKR--PSGSRKSNRQRSQRRP----------ILSDNP 818
               ..::|.....:.      ||.||.|.:.  |:..:.:...:|:::|          .:|..|
Human  1238 ---PANSGELDKMDE------KRTRLQPEEADVPAYPKVATVPQSEKKPSKYPLCSADAAVSTTP 1293

  Fly   819 AGH-----GLTEQDVEETRQSFN--TPTPDTRIDSKKRRSGAATTPISSIDSPA----------M 866
            .|.     .|.|..|.:...|..  .|:|.|...:....|.||::..||....|          .
Human  1294 PGSPPPPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHILQTLF 1358

  Fly   867 GDSVS-TPSSNDQTDINAALAPPP---AETLSKAP----QYIKENGELIRIVRMRQEEIINCICE 923
            |...| .||:.:.....|.|...|   ||....||    ..:::.|:..:...:.:|
Human  1359 GKKKSFDPSAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEE-------- 1415

  Fly   924 YGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLP 988
              |:|                     :..|..::|      :|:|..|:
Human  1416 --EDD---------------------RPYDPEEEY------DPERAFDT---------------- 1435

  Fly   989 VAAYHTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNL 1053
                           :|::|     |...:.:|:..:.                  |.:.:|...
Human  1436 ---------------QLVER-----GRRHEVERAPEAA------------------AAEREEVAY 1462

  Fly  1054 DSTALTPVKRAKLEAPDLPN----------VPQP----EAAIDPEECQYRLIEHIKVQQSLVLDR 1104
            |....|.::.||:...||||          |.:|    ..|..|.          .|:|..:|:.
Human  1463 DPEDETILEEAKVTVDDLPNRMCADVRRNSVERPAEPVAGAATPS----------LVEQQKMLEE 1517

  Fly  1105 LN-DIEAEMDELEKED 1119
            || .||.:..:||:::
Human  1518 LNKQIEEQKRQLEEQE 1533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	3/36 (8%)
		MeCP2_MBD	449..522	CDD:238690	11/80 (14%)
		PHD_SF	919..963	CDD:304600	4/43 (9%)
DIDO1	XP_011526806.1	TNG2	<160..302	CDD:227367
		PHD_DIDO1_like	266..319	CDD:277109
		TFS2M	708..809	CDD:128786	16/132 (12%)
		SPOC	1093..1199	CDD:285043	26/121 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030