Protein Alignment MBD-R2 and Nsd2

DIOPT Version :9

• Sequence 1: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001074571.2
• Gene: Nsd2 / 107823
• MGIID: 1276574
• Length: 1366
• Species: Mus musculus
• Alignment Length: 969
• Identity: 173/969 - (17%)
• Similarity: 284/969 - (29%)
• Gaps: 361/969 - (37%)

  Fly    98 QRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQILSESAERKATEEGKTGKAADDVKNTP 162
            |:.::...::.|.|..|:|...|.:    ..|:...:..||::....:.:||...|.
Mouse    13 QKVVKCMKMKQTPEILGSANGKTQN----CEVNHECSVFLSKAQLSNSLQEGVMQKF-------- 65

  Fly   163 ESGEDANKAAAKEP---------SGTPVAASSEATVPAPGSASSSNSPLPGTPPKYSNPH-NLTI 217
             :|.||......|.         :|.|.|..::....|. ......:|...||.|..:|. .|.|
Mouse    66 -NGHDALPFLPAEKLKDLTSCVFNGEPGAHDTKLCFEAQ-EVKGIGTPPNTTPIKNGSPEIKLKI 128

  Fly   218 ------GARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMAIKSERL 276
                  |..|...|:.|:. .|.:.:..|.||....:..||.|..:.
Mouse   129 TKTYMNGKPLFESSICGDG-AADVSQSEENEQKSDNKTRRNRKRSIK------------------ 174

  Fly   277 RQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQL 341
                                                    |:.|.:.|.|:   |..::|:
Mouse   175 ----------------------------------------YDSLLEQGLVE---AALVSKI---- 192

  Fly   342 PPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRDWPLLDMASL 406
                       .||.....||                        ||..|....||..||  ...
Mouse   193 -----------SSPADKKIPV------------------------KKESCPNTGRDRDLL--LKY 220

  Fly   407 DIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVI-VQDWRLPP--GWIKHMYQRSN 468
            ::..|...::.....|.| .|:..|:......:.|:.:..... ||.:...|  .||   :::|.
Mouse   221 NVGDLVWSKVSGYPWWPC-MVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWI---FEKSL 281

  Fly   469 VLGKWD--------------------VILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHR 513
            |..:.:                    :.|:.|...|.|::.::       .:|...:....||..
Mouse   282 VAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEM-------GIVQAEEAASMSIEE 339

  Fly   514 RRAKDINAYV--YTHGYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAPVAS 576
            |:||....||  ..| .|||...:...:...:...:|.|..|:.:... |..|:|.   :.|...
Mouse   340 RKAKFTFLYVGDQLH-LNPQVAKEAGIVTEPLGEMVDSSGASEEAAVD-PGSVREE---DIPTKR 399

  Fly   577 LMPPAELMSPQTQPAD-----ETKPKIEAEILEASEGGTSQLMLADPHVVENGFAFIGGLKVKIQ 636
            ........|.:.|..|     .|.||: ||              |:|   :.|.....|.|....
Mouse   400 RRRTKRSSSAENQEGDPGTDKSTPPKM-AE--------------AEP---KRGVGSPAGRKKSTG 446

  Fly   637 DNLYVCPREDCAKTYRKED----FLLIHIRHYHKEFAEHV-SHCPKMQEL--------------- 681
            .    .||.      ||.|    ||:...:|..:..|||. :...:::||
Mouse   447 S----APRS------RKGDSAAQFLVFCQKHRDEVVAEHPDASGEEIEELLGSQWSMLNEKQKAR 501

  Fly   682 ---------------------AVKRTHPSSIDQ-VEAVPKNQIPNQQFFAKMHQQDLQQSRSFKR 724
                                 ..||:|....|. .|.|.....|.::..|..|        |.::
Mouse   502 YNTKFSLMISAQSEEDSGNGNGKKRSHTKRADDPAEDVDVEDAPRKRLRADKH--------SLRK 558

  Fly   725 QSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRA 789
            |..:.|..::..|.....:|..|.|                         :|:...:||.:||
Mouse   559 QRETITDKTARTSSYKAIEAASSLK-------------------------SQAATKNLSDACK-- 596

  Fly   790 RLSPSKRPSGSRKSNRQRSQRRPIL----SDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRR 850
               |.|      |.||..:.....|    |.:|:. .|||.:|.
Mouse   597 ---PLK------KRNRASATASSALGFNKSSSPSA-SLTEHEVS--------------------- 630

  Fly   851 SGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAET-LSKAPQYIKENGELIRIVRMRQ 914
                       |||....|.|...|.|:|...|:::...:|. ::...:|
Mouse   631 -----------DSPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEY--------------- 669

  Fly   915 EEIINCICEYGEEDGLMIQCELCLCWQ-HGACNGIVKEAD--------VPDKYVCYICR 964
                  :|:..|:.|.::.||...|.. |.||.|:.:..:        ....:.|::|:
Mouse   670 ------VCQLCEKTGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCK 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	4/36 (11%)
		MeCP2_MBD	449..522	CDD:238690	17/95 (18%)
		PHD_SF	919..963	CDD:304600	11/52 (21%)
Nsd2	NP_001074571.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..169		5/19 (26%)
		MSH6_like	218..337	CDD:99898	18/129 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..455		24/113 (21%)
		HMG-box	460..>505	CDD:238037	8/44 (18%)
		TNG2	<546..711	CDD:227367	47/262 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..659		23/107 (21%)
		PHD1_NSD1_2	670..712	CDD:277118	10/41 (24%)
		PHD2_NSD2	717..763	CDD:277121	2/6 (33%)
		PHD3_NSD2	764..817	CDD:277124
		PHD_SF	834..874	CDD:389947
		WHSC1_related	879..972	CDD:99899
		AWS	1013..1063	CDD:197795
		SET_NSD2	1063..1204	CDD:380988
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:O96028	1116..1119
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:O96028	1142..1143
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1207..1233
		PHD5_NSD2	1242..1284	CDD:277130
		C5HCH	1283..1328	CDD:375464
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1330..1366

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030