DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and si:ch211-69l10.4

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_005162657.1	Gene:	si:ch211-69l10.4 / 101883218	ZFINID:	ZDB-GENE-131127-259	Length:	306	Species:	Danio rerio

Alignment Length:	311	Identity:	65/311 - (20%)
Similarity:	99/311 - (31%)	Gaps:	112/311 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CCVANCPSTSRLLEHNGVTYHSFPLDPIIRAIWIKNSRISLERQITKSVL-----VCSRHFRRLD 64
            |.|..|.|..|...:  :::|:||.....|..|:  ..|..:..:|.::|     ||||||...|
Zfish    10 CSVPYCSSNKRRQPY--LSFHAFPSCKYDRKKWV--HVIRRDESLTFNILRGSTYVCSRHFIEAD 70

  Fly    65 FNTIRNGKYLLKPRVFPTVFPWGKMDTAEIEADQRALQHASVEGTTETPGNAQSSTNDDVIKATV 129
            : |...|:..|:....|:.|.|...                        |::...|
Zfish    71 Y-TAATGRKRLRKGAVPSRFHWNNW------------------------GDSSRLT--------- 101

  Fly   130 DQIVAQILSESAERKATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVAASSEATVPAPGS 194
                  :.....:|:..:..:.|....:|  .|::|.|.:.|.|
Zfish   102 ------VYDGGVDRRGLDPSQNGDIVPEV--PPKAGADHDYAVA--------------------- 137

  Fly   195 ASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSP 259
                  ||||...        ...||::.|..|        |...|||.         .:||::.
Zfish   138 ------PLPGAQD--------AAAARIQELEAE--------VRRLETEL---------GQLKINQ 171

  Fly   260 STSGSFQEWMAIKSERLR---QRLSNRVLPVF----ELDEKCMARWSGPRK 303
            |.| .||.:.| ..|.:|   ...|.:|...|    |.....|..||..:|
Zfish   172 SLS-QFQRFCA-SDEDIRFYTSFPSEKVFLAFWKAIEPSASMMVYWSLAQK 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	25/85 (29%)
		TUDOR	292..329	CDD:119391	4/12 (33%)
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600
si:ch211-69l10.4	XP_005162657.1	THAP	9..91	CDD:283206	25/85 (29%)
si:ch211-69l10.4	XP_005162657.1	HTH_Tnp_4	235..287	CDD:290344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11795
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910