DRSC/TRiP Functional Genomics Resources

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Protein Alignment MBD-R2 and kmt2d

DIOPT Version :9

Sequence 1:NP_731688.2 Gene:MBD-R2 / 41498 FlyBaseID:FBgn0038016 Length:1169 Species:Drosophila melanogaster
Sequence 2:XP_009295228.1 Gene:kmt2d / 100536523 ZFINID:ZDB-GENE-060223-2 Length:4967 Species:Danio rerio


Alignment Length:1472 Identity:251/1472 - (17%)
Similarity:449/1472 - (30%) Gaps:552/1472 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 TIRNGKYLLKPRVFPTVFPWGKMDTAEIEADQRALQHASVEGTTETPGNAQSSTNDDVIKAT--- 128
            |.|:.:.||:|.:     |.....||..|:.:...:.:.:....:..|....:|.|..:..:   
Zfish  1244 TPRHTQGLLRPPL-----PGLGARTAASESVESTARPSGLPMELKQEGEGSKATGDGAVVGSGAT 1303

  Fly   129 ---------------VDQIVAQILSESAERKATE----------EGK--TGKAADDVKNTPESGE 166
                           .|.:..:.|.:..||:.:|          ||.  :|:....:|...|.  
Zfish  1304 GQLFNKDQSSGAAHGSDMLKNKDLPQGLERQDSEQFFRKVLGPTEGSSVSGQLQPSIKPVQEG-- 1366

  Fly   167 DANKAAAKEPSGTPVAASSEATVPAPGSASS----SNSPL----------------------PGT 205
            |.|:::..:.:..| .||...|:|:.|...|    |.||.                      |.|
Zfish  1367 DPNQSSCPQRNLLP-GASLSGTLPSTGMMDSFSGLSQSPFFDLRDRGGLFSPDQDEESPWATPST 1430

  Fly   206 PPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKL----KVS-------- 258
            |...|.|...|        ..||:.|        ...|..|.|:|::.:|    .:|        
Zfish  1431 PATPSTPPTPT--------EQEGDGL--------SYNQRSLQRWEKDEELGNLSTISPVLYANMN 1479

  Fly   259 -PSTSGSFQEWMA-----------------------IKSERLRQRLSNRVLPVFELDEKCMARWS 299
             ||....:.:|.:                       .|..|..||::       :..::..::..
Zfish  1480 FPSLKQDYPDWASRCKQIMKIWRKVSAADKVPYLQKAKDNRAAQRIN-------KAQKQAESQVC 1537

  Fly   300 GPRKF-PGTIR------------------------------KLLGNDTYEVLFDDGYVK-----N 328
            .|.|. ||.|:                              .|..:......|.||.:|     :
Zfish  1538 RPIKTEPGRIKGERPNLHLQIPPPSGSVSTSSQPSSAESPYTLAPDSASSAFFPDGPLKTPCSAD 1602

  Fly   329 VRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAP 393
            ::|...:|:..|.|.:|      |:..||...| ||:|: |..:|...:.|..|::..:.|    
Zfish  1603 LQADPFSKLSSQSPHLQ------SQPSTPYSQP-SSSPL-PASSSGHCMPGPQGATQGRPS---- 1655

  Fly   394 QRRDWPLLDMASLDI-------------------------ASLGLPEIPHDGEWTCHWVNDQPIG 433
                    ...||::                         .:||.||.|          ..:|.|
Zfish  1656 --------SFGSLEMQPGATRRAQQVDPFFRPQQQIPKPQEALGPPESP----------RPRPGG 1702

  Fly   434 TEGFLIVGEHQKPTVIVQDWRLPPGWIKH---MYQRSNVLGKWD--------VILVSPSGKRFRS 487
            .      |:.|         ...|..:.|   :|:..:..|:.|        .|..||:|.. .|
Zfish  1703 P------GDAQ---------MFSPPHMTHCGDLYRGQHGAGRQDHASSPSPSAIASSPAGVG-PS 1751

  Fly   488 KSDLKL------------------FLESQN---------LVYNPDVYDFSIHRRRAKDINAYVYT 525
            ::|:.:                  .|:|.:         .::..|....|:..:.....|..:.:
Zfish  1752 RADINVPSPRSSFGRQDLNTGSPASLDSGDGLFKAPMTPRMHQGDAGGLSVSHQSGASPNHPLES 1816

  Fly   526 HGYNP--------QPPPKPRPMDVSMNSTLDQSITSQHS-----LPSTPMPVKESQYMEAP---- 573
            :..:|        |||..|||.....:|.|.|.:.:...     |||:|.....||....|    
Zfish  1817 YRQSPSTFSDPYAQPPLTPRPQSGDGSSPLPQRLPAAQQEAYSRLPSSPQSQGSSQSPLTPGAIS 1881

  Fly   574 --VASLMPPA----ELMSPQTQP----------ADETKPKIEAEILEASEGGT--------SQLM 614
              |.|:..||    :...|.::|          |...||...:.:  |.||.:        .|..
Zfish  1882 NDVLSVQSPATPRFQSPDPYSRPPSRPQSRDPFASLHKPPRPSSV--APEGNSPFRGSPHPGQQP 1944

  Fly   615 LADPHVVE------NGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAE--- 670
            ...|.|.:      ..|:...|:.:::.      |::...:.:.......:|::....:..:   
Zfish  1945 PCSPSVADPLSGKPPAFSCSPGVGIQMG------PQQIVGQQHMTPQQAQVHLQQPQSQTQQVGA 2003

  Fly   671 -----------------------HVSHCPKMQEL---------AVKRTHPSSIDQVEAVPKNQIP 703
                                   |:.:.|.||::         |:....||.:::..  .:.::.
Zfish  2004 DFNSRIALPPGNQDTAVRPSDGPHLPNIPGMQDISDMSAAQDPALMSLSPSELEKHR--QRQRLR 2066

  Fly   704 NQQFFAKMHQQDLQQSRSFK-----------------RQSVSATATSSTPSD-ITPTKALLSPKM 750
            ......||.:..|:|.:...                 :|..|..|....|.| ...|:|.|:.:|
Zfish  2067 EFLIRQKMQRNSLRQEKEAPVVSNPAQSWQDGEMPAFQQDKSQRAPPPYPQDRAAVTQAALASRM 2131

  Fly   751 --------------EPPSVSPTVE-SGIKQE-DVSLDAGPTQSF--------------NPSLSRS 785
                          .||.....:: |.::|. .||....|...|              .||:..:
Zfish  2132 PLPMGVMDEKLCRPPPPGTPANMDPSALRQAGPVSQGMYPRPQFPAQWQNQGAPRRFPQPSMIEA 2196

  Fly   786 CKRARL-SPSKRPSGSRKSNRQRSQRRPILSDNP------------AGH--GLTEQDVEETRQS- 834
            ..|..| :|...|     .|.|..|..|    ||            ..|  |...|.:|....| 
Zfish  2197 VPRQHLTTPINNP-----LNMQSMQNMP----NPLTTVPGTGTEAVQSHVSGAPPQFIELRHNSQ 2252

  Fly   835 ---------FNTPTPDTRIDSKKRRSGAATTP---ISSIDSPAMG-------------DSVSTPS 874
                     ...|.|..|:...::...||...   .||:|:.|:|             |.:....
Zfish  2253 RMPPGPQFMQRAPIPRARMFLPQQEMNAAFAQQNLTSSLDASAVGMRDPRLGLQQGGMDLLMQQQ 2317

  Fly   875 SNDQTDINAALAPPP------------------AETLSKAPQYI----KENGELIRIVRMRQEEI 917
            ||         ||||                  :.|..:.||..    ::.|  :..|.:.:.::
Zfish  2318 SN---------APPPQSQLQPQQVPTTTPKTQISHTTQQLPQTTSIGSQQTG--VNPVDLPESDL 2371

  Fly   918 INCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSM--------R 974
            ::.....|..|.                   |.|..|.|..: .:..:|.:|.|.:        .
Zfish  2372 VDAFAPKGLSDP-------------------VAETGVEDDDL-GLDLDPDKGDDDLGNLDNLEAN 2416

  Fly   975 FKHDQDWLFEGKLPVAAYHTANPQA---------TKQFELLKRSHTLTGNLLDAKRSMHSLLVKI 1030
            ..|..|.|...:..:.||  .:|:.         :.|..|::..       ::...|..::.||:
Zfish  2417 DPHLDDLLNSDEFDLLAY--TDPELDQGDPKDVFSDQLRLVEAE-------VEGPVSSANVEVKV 2472

  Fly  1031 NIARNRCHPKLYLWAKKWDEDNLDSTALTPVKRAKLEAPDLPNVPQPE----AAIDPEECQYRLI 1091
            .:     .||:.:.:    :|...:....|:|.....|.:.|.|...:    :::..|:  ..|:
Zfish  2473 EV-----KPKVEMAS----QDTRTTATQPPLKTENSSAVNTPKVESSDVISLSSVKLED--KGLV 2526

  Fly  1092 EHIKVQQSLVLDRLNDIEAEMDELEKEDTLDDLKDADISTTK 1133
            |..:..|:.|.|.:::..:.:....|.....|...|:::|.:
Zfish  2527 EQPQSGQASVKDDISETVSVLLSGTKASNQPDTPTANLNTVR 2568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MBD-R2NP_731688.2 THAP 4..86 CDD:283206 5/18 (28%)
TUDOR 292..329 CDD:119391 10/72 (14%)
MeCP2_MBD 449..522 CDD:238690 16/110 (15%)
PHD_SF 919..963 CDD:304600 6/43 (14%)
kmt2dXP_009295228.1 PHD_SF 122..205 CDD:304600
PHD1_KMT2C_like 218..263 CDD:276984
PHD_SF 265..310 CDD:304600
PHD 346..391 CDD:214584
PHD_SF 821..871 CDD:304600
PHD5_KMT2C_like 872..918 CDD:276988
PHD5_KMT2D 949..999 CDD:277074
HMG 1473..1528 CDD:197700 7/61 (11%)
Med15 3305..>3717 CDD:255446
PHD_SF 4462..4568 CDD:304600
FYRN 4612..4662 CDD:283589
FYRC 4668..4749 CDD:283590
SET 4828..4949 CDD:214614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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