Protein Alignment MBD-R2 and mecp2

DIOPT Version :9

• Sequence 1: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001135563.1
• Gene: mecp2 / 100216110
• XenbaseID: XB-GENE-494740
• Length: 466
• Species: Xenopus tropicalis
• Alignment Length: 514
• Identity: 101/514 - (19%)
• Similarity: 170/514 - (33%)
• Gaps: 211/514 - (41%)

  Fly   444 QKPTVI------VQDWRLPPGWIKHMYQRSN--VLGKWDVILVSPSGKRFRSKSDL-KLFLESQN 499
            |:.:||      .:|..||.||.:.:.||.:  ..||:||.|::|:||.||||.:| ..|.:..:
 Frog    84 QRRSVIRDRGPMYEDPTLPEGWTRKLKQRKSGRSAGKFDVYLINPNGKAFRSKVELIAYFQKVGD 148

  Fly   500 LVYNPDVYDFSI------HRRRAKDINAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQ-HSL 557
            ...:|:.:||::      .||..|             ||.....|         ..|.|.: ...
 Frog   149 TSLDPNDFDFTVTGRGSPSRREQK-------------QPKKSKAP---------KSSGTGRGRGR 191

  Fly   558 PSTPMPVKESQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLMLADPHVVE 622
            |...:.||                   ||......:.|     .::|.|.|   :|::..|
 Frog   192 PKGSVKVK-------------------SPVKSEGVQVK-----RVIEKSPG---KLLVKMP---- 225

  Fly   623 NGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKR-- 685
                |.|.             :|:...|..:                         |.|.:||
 Frog   226 ----FSGS-------------KEESDATTSE-------------------------QVLVIKRPG 248

  Fly   686 ------THPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKA 744
                  |.||      |.||                   .|..|..|||..|.::        :|
 Frog   249 RKRKSDTDPS------AAPK-------------------KRGRKPGSVSLAAAAA--------EA 280

  Fly   745 LLSPKMEPPSVSPTVESGI------KQEDVSLDAGPT---QSFNPSLSRSCKRARLSPSKRPSGS 800
            .....::..|:.|.:|:.:      .:|.:|:|...|   :...|.:.:|.|..:  |:|.|..
 Frog   281 AKKKAIKESSIKPLLETVLPIKKRKTRETISVDVKDTVKPELLTPVIEKSIKGQK--PAKSPES- 342

  Fly   801 RKSNRQRSQRRPILSDNPAGHGLTEQDVE---------------ETRQSFNTPTPDTRIDS---- 846
                 :.::..|.:..     ||.:::::               |::.|..:|.|:|..||
 Frog   343 -----RSTEGSPKIKT-----GLPKKELQQHHHHHHHHHHHHHSESKASATSPEPETSKDSIGAP 397

  Fly   847 ----------KKRR----SGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAE 891
                      |:.:    .|.|..|..:  .||  |.....:..::.||.:::..|..|
 Frog   398 EPQDLSVKIYKEEKLPESDGCAQEPAKT--QPA--DKCRNRAEGERKDIVSSVPRPTRE 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690	28/87 (32%)
		PHD_SF	919..963	CDD:304600
mecp2	NP_001135563.1	MBD	93..170	CDD:128673	25/76 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12098
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000