Protein Alignment MBD-R2 and phf20

DIOPT Version :9

• Sequence 1: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: XP_004918557.1
• Gene: phf20 / 100126218
• XenbaseID: XB-GENE-960341
• Length: 1098
• Species: Xenopus tropicalis
• Alignment Length: 1185
• Identity: 229/1185 - (19%)
• Similarity: 415/1185 - (35%)
• Gaps: 389/1185 - (32%)

  Fly   217 IGARLEALSVEGNWLPARIVEVNETEQTLLVRFER-NHKLKVSPSTSGSFQEWMAIKS------E 274
            :||:|||......|..|.|.|::..|..:|:.|:| ||:          :.||....|      |
 Frog    15 VGAQLEARDRLKKWYAAHIEEIDYEEGKVLIHFKRWNHR----------YDEWFCWDSPYLRPLE 69

  Fly   275 RLRQRLSNRVLP----VFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMN 335
            :::.|....|..    ||.::|:.:|.||..|.:|..|.....:.||.|.|.||.|:.|:.:|:.
 Frog    70 KIQLRREGLVEDEQHVVFRVNEQVLACWSDCRFYPAKIISANKDGTYTVKFFDGVVQTVKNIHVK 134

  Fly   336 KMPKQL---PPVQVAE---EGASKS-----------PTPVGT-PVSSAPVAPKRAST-------- 374
            ...|..   |.::|.|   ||.|.|           .:...| ||....:||::.|:
 Frog   135 AFSKDQENGPRLKVKEKCREGTSPSDKYRAKFKEQRKSAENTHPVKEKSIAPEKKSSQPEREKKP 199

  Fly   375 -----GSLGGSSGSSGSKKSK-------------CAPQRRDWP---------------------- 399
                 ..:...:|....|:.|             |..:.|..|
 Frog   200 VVSEKSKIPEKNGVKNEKEDKENISENERESSGDCRQEERSTPSESLKTPLENGDRRKKRDRPTT 264

  Fly   400 ---------LLDMASLDI----ASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQ 451
                     .|...:|::    .|:| .|||                |:...:....:|.....:
 Frog   265 APPSDSVSQTLQPVTLELRRRKISIG-SEIP----------------TKRSRLDKSTKKSLPASE 312

  Fly   452 DWRLPPGWIKHMYQRSNVLGKWD-----VILVSPSGKRFRSKSDLKL---FLESQNLVYNPDVYD 508
            :.::..|..:.::..::.:.:.:     :.|.|...:...|:::.|.   ..|.:.:...|:|..
 Frog   313 NVKVENGLPEELHPEADDICETEDTLSPLSLSSCESQEKLSENEEKTTAPLTEEEGVSQEPNVTS 377

  Fly   509 FSIHRRRAKDINAYVYTHGYNPQ---------PPPKPRPMDVSMN----STLDQSITSQHS---- 556
            .....         |:|....|.         |......:::|:|    ||.|......:|
 Frog   378 METQE---------VHTESLTPSNTEQSEAKTPTETDDFVELSVNDVPSSTPDMKAEENNSTESK 433

  Fly   557 ----LPSTPMPVK-------ESQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEASEGGT 610
                :||.|.|:|       .::|...|:...:          :.:|:..||
 Frog   434 QNQEVPSVPAPMKRIPRSDTSAKYSREPLTHAL----------KKSDDPAPK------------- 475

  Fly   611 SQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHC 675
                               .:.:::..|.:.|...||:|::||...|..|::::|
 Frog   476 -------------------AVTMELDPNRFKCKFLDCSKSFRKAKLLHYHMKYFH---------- 511

  Fly   676 PKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDIT 740
                             .:|...::|.|     ...|.| .:.|.:.::.|........|.|...
 Frog   512 -----------------GIEKAEQDQSP-----VTRHMQ-TRGSLAHEKSSQETPKRRRTTSGSL 553

  Fly   741 PTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNR 805
            .|...:|.:..|..                  |..:........|...:..|.|.|||...||..
 Frog   554 HTPLQISLRSSPQD------------------GKAERLGEKRRHSMHASYTSNSHRPSLKEKSKE 600

  Fly   806 QRSQRRPILSDNPAGHGLTEQDV-EETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAMGDS 869
            .:.|:....||..:.....::.: |:.:.|.|......:...||.|
 Frog   601 NQIQKTHSKSDKQSESVKDKEKIREKLKDSLNLKARKKKKKKKKPR------------------- 646

  Fly   870 VSTPSSNDQTDINAALAPPPAETLSKAPQY-----IK---------------------------- 901
            :....|.:..||:..|:|...:.:.::|.:     :|
 Frog   647 LENSGSEENLDISKELSPKKTQVIKQSPDFKPSSQVKSAPLRSSEHGRRKDTGRLSDEDTLSDSC 711

  Fly   902 ----------ENGELIRIVRMRQE--------EIINCICEYGEEDGLMIQCELCLCWQHGACNGI 948
                      :|.|.|.:....:|        ||:.|:||..:|:..|||||.|||||||.|.|:
 Frog   712 TESLLWSDDDDNNEEIDVTNADEELEEEPGDCEIVRCMCEVQDENDFMIQCEECLCWQHGVCMGL 776

  Fly   949 VKEADVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGK---LPVAAYHTANPQATKQFELLKRSH 1010
            : |.:||:||.||||::|...|.|:::.:|::||.:|.   |.....:.::..|.|    :..:|
 Frog   777 L-EDNVPEKYKCYICQDPPGQRLSLKYWYDKEWLDKGHMHGLSCLEENYSHQNARK----IVATH 836

  Fly  1011 TLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNLDSTALTPVKRAKLE-------- 1067
            .|.|::......:|.|.:|::|.:::.||.|..|.:.|.:..::....  ::|:..|
 Frog   837 QLLGDVQRVIEVLHGLQLKMSILQSKEHPDLKFWGQPWKQQAVNDKCY--IRRSLEENSCKGDST 899

  Fly  1068 -------APDLPNVPQP---EAAIDPEEC-QYRLIEHIKVQQSLVLD-RLNDIEAEMDEL--EKE 1118
                   |.|.|: |.|   |:.|..|.| |.....:..|:|.||:: |.:.::..::.:  .:|
 Frog   900 NHRTYNGAVDKPS-PIPSVEESYITSEHCYQKPRTYYPAVEQRLVVETRSSALDGGVERIRQSRE 963

  Fly  1119 DTLD-----DLKDADISTTKEALATFIKELETMKRLA------------------------KLNQ 1154
            |::.     :|....|.|..|:...:.|..|.:.:..                        :||.
 Frog   964 DSIAERLGWELDRELIKTESESKHNYCKVRECLSKRNPPQESTHPQPTDISDGGVSSQIQWQLNL 1028

  Fly  1155 VANMKQTLRDSATSK 1169
            :|:: ::|:|..|.:
 Frog  1029 LAHL-ESLQDEVTHR 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	14/36 (39%)
		MeCP2_MBD	449..522	CDD:238690	8/80 (10%)
		PHD_SF	919..963	CDD:304600	25/43 (58%)
phf20	XP_004918557.1	Tudor-knot	13..57	CDD:288553	15/51 (29%)
		TUDOR	90..135	CDD:119391	16/44 (36%)
		DUF3776	180..252	CDD:289391	9/71 (13%)
		PHD_PHF20	747..790	CDD:277104	25/43 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	147	1.000	Domainoid score	I4477
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3838
OMA	1	1.010	-	-		QHG47145
OrthoDB	1	1.010	-	-		D147824at2759
OrthoFinder	1	1.000	-	-		FOG0001785
OrthoInspector	1	1.000	-	-		otm47941
Panther	1	1.100	-	-	LDO	PTHR15856
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X2262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.200