Protein Alignment MBD-R2 and nsd2

DIOPT Version :9

• Sequence 1: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001076020.1
• Gene: nsd2 / 100000709
• ZFINID: ZDB-GENE-030131-2581
• Length: 1461
• Species: Danio rerio
• Alignment Length: 1119
• Identity: 218/1119 - (19%)
• Similarity: 343/1119 - (30%)
• Gaps: 421/1119 - (37%)

  Fly   138 SESAERKATEEGKTGKAADDVKNTPESGEDA------------NKAAAKEPSGTPVAASSEATVP 190
            |:.....|..|.|:..:...:.::| .|.:.            ||||      |.:||:.:.:||
Zfish     4 SKGGSLPAMPEPKSPTSMKQLSDSP-GGRNGLVDGITDPTMLMNKAA------TQLAATPQESVP 61

  Fly   191 APGSASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRFE--RNH 253
            ....:...|         :::.|...:.:||  |:.:...:|.....  ...|.||...|  ..|
Zfish    62 QMIGSHGHN---------HTHEHLKDLTSRL--LNGDTEKIPKLCAA--PAGQPLLKGVEPVSQH 113

  Fly   254 KLKVSPSTSGSFQEWMAIKSERLRQRLS---NRVLPVFELD--EKCMARWSGPRKFPGTIRKLLG 313
               .||....|....:.:|..:....|.   ||    :|:|  |:.......|.:.|
Zfish   114 ---ASPPRKTSVSPELTVKITKCVVNLGGKPNR----YEVDYTEEKAEETDAPLRLP-------- 163

  Fly   314 NDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQVAEEGASKS------PT---------PVGTPVS 363
                |.:......:..|......:.|::||..:....||..      ||         |.|.||.
Zfish   164 ----EGVLTSPTARRDRQKKKGMVRKRIPPYPILTHAASSDQSPLLHPTINSNDITIEPCGLPVE 224

  Fly   364 S------------------APVAPKRASTGSLG-----GSSGSSGSKKSKCAPQRRD-------- 397
            |                  .|::....:..:.|     .:.|.:..|:|....|...
Zfish   225 SIEHTHGDMPTCVTAFPDEQPLSDCEETVDAQGVDETDDAQGENDVKESYTETQSNVHFSVGDVI 289

  Fly   398 ---------WPLLDMASLDIASLGLPEIPHDGEWTCHW---VNDQPIGTEGFLIVGEHQKPTVIV 450
                     ||.:              |..|.|:..|:   ||.:    .|.|.   |      |
Zfish   290 WTKVSGYPWWPCM--------------ITTDPEFNMHFRSKVNSR----TGLLY---H------V 327

  Fly   451 QDWRLPP--GWI----------KHMYQ---RSNVLGKWDVILVSPSG------KRFRSKSDLKL- 493
            |.:...|  |::          ||.||   |||.|.      ::.||      ::||.|.::.:
Zfish   328 QYFGDTPERGYVFEKCIVTFSGKHQYQSLSRSNQLP------INISGRKRAVPRKFRQKWEIGVS 386

  Fly   494 -FLESQNLVYNPDVYDFSIHRRRAKDINAYVYTHG---YNP--------------QPPPKPR--- 537
             ..|:..|:....:..||           :||..|   .||              |..|..|
Zfish   387 QAKEALGLLTEERLAKFS-----------FVYEDGKAQLNPHMLQVLEEQRNQGLQEEPVQREPQ 440

  Fly   538 ------PMDVSMNSTLDQSITSQ-HSLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPADETK 595
                  |.|.:.:|..:.|.||. .||.|.|:....|....|    |...|...|.:|....:..
Zfish   441 ELVSLTPPDSTHSSPTNSSTTSTIPSLFSNPIDSSTSSGKTA----LPRKARKPSVKTNRRKQRS 501

  Fly   596 PKIEAEILEASEGGTSQLMLADPHV-----VENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKED 655
            ..||..:.|||  ...|:.|.:..|     .|:        |.|.:.|....|       |||:|
Zfish   502 STIEWIVTEAS--SAKQMPLTESTVQCEVNTEH--------KKKGKTNAGKRP-------YRKKD 549

  Fly   656 FLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSR 720
            .|.|.:....|...:...|        :::..|::.:.|:
Zfish   550 LLCIDLDLQPKASQKKPRH--------IRQKFPAAPNSVK------------------------- 581

  Fly   721 SFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRS 785
              ||:..:..:...|.:.::.:..|...|...||....     ::||.|         :..:.:.
Zfish   582 --KRKIKAGVSICDTLNTVSTSAGLSEVKASAPSTKLW-----EKEDAS---------SKGMKKV 630

  Fly   786 CKRAR-------LSPSKR-------------------------PSGSRK-----SNRQRSQRRPI 813
            |||:|       |.|.|:                         |.|.|:     .||:||::...
Zfish   631 CKRSRESKQDVTLQPKKKSKLEKDFKKWKCPKAASSAPAAVPAPRGRRRKTDRDENRKRSKKASK 695

  Fly   814 LSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAMGDSVSTPSSNDQ 878
            ....|......::..|..||||..        |||.|.       ||...|...||.|     |.
Zfish   696 EEPPPKAKRGRKRKEESGRQSFPA--------SKKCRP-------SSYAEPERPDSPS-----DS 740

  Fly   879 TDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCE-LCLCWQH 942
            ||     ...|::...:.|...||:              :..:||...||  ::.|. .|....|
Zfish   741 TD-----ESHPSKKAERTPGAKKES--------------VCLVCEQTGED--IVTCAGQCYGTYH 784

  Fly   943 GACNGIVKEAD-------VPDKYVCYICRNPQR------GRDSMRFKHDQD------WLFE---- 984
            ..|.|:.:.|:       ....:||:.|:..:.      .....||.|:..      .:||
Zfish   785 LHCIGVERSAEKILCTACSTGVHVCFTCKKSEGEVRRCCALHCGRFYHEACVRLSALTVFENRGF 849

  Fly   985 ----------------------GKL------PVAAYHTANPQATKQFELLKRSHTLTGNLLDAKR 1021
                                  ||:      || |||..:.......|::..|..:..|...||:
Zfish   850 RCPLHTCLSCHYSGRAACKATKGKMMRCLRCPV-AYHVGDLCVAAGSEMISSSAIVCTNHFRAKK 913

  Fly  1022 --SMHSLLVKINIA 1033
              |.||   .:|::
Zfish   914 GYSHHS---HVNVS 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	4/36 (11%)
		MeCP2_MBD	449..522	CDD:238690	21/95 (22%)
		PHD_SF	919..963	CDD:304600	12/51 (24%)
nsd2	NP_001076020.1	PWWP	283..394	CDD:295359	29/143 (20%)
		DTHCT	688..>758	CDD:285332	23/94 (24%)
		PHD_SF	761..803	CDD:304600	10/43 (23%)
		PHD_SF	808..854	CDD:304600	8/45 (18%)
		PHD_SF	855..908	CDD:304600	9/53 (17%)
		PHD4_NSD2	925..965	CDD:277127	218/1119 (19%)
		WHSC1_related	970..1063	CDD:99899
		AWS	1103..1153	CDD:197795
		SET	1154..1277	CDD:214614
		PHD_SF	1329..1371	CDD:304600

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030