DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10013 and Ube3d

DIOPT Version :9

Sequence 1:	NP_650175.2	Gene:	CG10013 / 41494	FlyBaseID:	FBgn0038012	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001034699.1	Gene:	Ube3d / 315863	RGDID:	1306773	Length:	370	Species:	Rattus norvegicus

Alignment Length:	246	Identity:	53/246 - (21%)
Similarity:	102/246 - (41%)	Gaps:	45/246 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 GLYLRRIRYSILDALTINVELGELPMCISPYNS-------CSLHCSNCTNEIIGQRQYYHIQEVP 149
            ||:||           :..:....|..||.:|.       ||.:|.:|....|..|:...:..:|
  Rat    78 GLHLR-----------LRAQAESSPQPISGFNQSLQAQECCSFYCQSCGEVTIKDRKLLRVLPLP 131

  Fly   150 IT--TILPQNYFC---PRNRIPVYPSEEELYYGLNYLVVCSELLGNGVKTIAGRRRVLCSRCKKC 209
            ..  :.|...:.|   |....|::|.|.:.:.|.::.:|.|.  .:..:......:|:|.|||..
  Rat   132 SENWSALVGEWCCHPDPFANKPLHPRENDCFVGDSFFLVNSR--SDLEQEPKANTKVICKRCKVM 194

  Fly   210 VGEFITRDVGVQLYADALRFVTLDSPLEFKE-IFGHVTPTQIMMRLVND--GEICGPDQRRLFLK 271
            :||.::        ::..:|...:..::..| .|.::..:|.:..::..  .|:|  ..|..|..
  Rat   195 LGETVS--------SETTKFYMTEVIVQPSEGSFPNIPRSQFVQSVIARCLVELC--TARSTFRF 249

  Fly   272 AVR-PDGQLQLL--HLEMDTKQMHILRSELKLPDIKK-PDIDLPMEVDTSS 318
            .:: .||::.:|  .|..|:..|..|.|.   ..|:| |.::..:|.|:.|
  Rat   250 TIQGQDGKVYILLWVLNSDSLVMEPLSSS---GCIRKFPLLEDSLEADSGS 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10013	NP_650175.2	HECT_2	<125..>256	CDD:303071	27/136 (20%)
Ube3d	NP_001034699.1	HECT_2	13..358	CDD:286852	53/246 (22%)
		Interaction with UBE2C. /evidence=ECO:0000250	214..236		3/21 (14%)
		HECT-like. /evidence=ECO:0000250	332..368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4784
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900