DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svp and Rxrg

DIOPT Version :9

Sequence 1:	NP_001369011.1	Gene:	svp / 41491	FlyBaseID:	FBgn0003651	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	XP_038947050.1	Gene:	Rxrg / 83574	RGDID:	620046	Length:	464	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	175/467 - (37%)
Similarity:	246/467 - (52%)	Gaps:	75/467 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PSANGGSAGGHHSGSGSGSGSGVNP-GHGSDMLPLIK--------------------GHGQDMLT 160
            |:..|||.|  |:||.|.|.|...| |...|..|...                    |....::|
  Rat    12 PTGFGGSPG--HTGSTSMSPSVALPTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVIT 74

  Fly   161 SIKGQPTGCGS--------TTPSSQANSSHSQSSNS---------------------GSQIDSKQ 196
            |..|.|:|..:        ..||||.|..:|.||:.                     ||.:   :
  Rat    75 SAMGPPSGALAAPPGINLVVPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLV---K 136

  Fly   197 NIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYSCRGSRNCPIDQHHRNQCQYCRLKKCL 261
            :| |.:|||:|||||||.::|||||.||||::|::|.|:||.:::|.||:..||:|||||.:|||
  Rat   137 HI-CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCL 200

  Fly   262 KMGMRREAVQRGRVPPTQPGLAGMHGQYQIANGDPMGIAGFNGHSYL--SSYISLLLRAEPYPTS 324
            .|||:|||||..|    |........:.:.|:         .||..:  ...:...|..|| .|.
  Rat   201 VMGMKREAVQEER----QRSRERAESEAECAS---------TGHEDMPVERILEAELAVEP-KTE 251

  Fly   325 RYG-QCMQPNNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQ 388
            .|| ..::.:....:.|||..|.:.||:.|||||.||.|.:|.:.|||.|||..|:||.:.:.|.
  Rat   252 SYGDMSVESSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSH 316

  Fly   389 CSMPLHVAPLLAAAGLHASPMAADRV-VAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT 452
            .|:.:... :|.|.|||....:|... |..:...|:..|.|.|:|.:.:|.:|..||:|||||..
  Rat   317 RSVSVQDG-ILLATGLHVHRSSAHSAGVGSIFDSRVLTELVSKMKDMRMDKSELGCLRAIVLFNP 380

  Fly   453 DACGLSDVTHIESLQEKSQCALEEYCRTQYPNQPTRFGKLLLRLPSLRTVSSQVIEQLFFVRLVG 517
            ||.|||:.:.:|:|:||....||.|.:.:||.||.||.|||||||:||::..:.:|.|||.:|:|
  Rat   381 DAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIG 445

  Fly   518 KTPIETLIRDML 529
            .|||:|.:.:||
  Rat   446 DTPIDTFLMEML 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	45/71 (63%)
svp	NP_001369011.1	NR_LBD_COUP-TF	307..542	CDD:132746	92/227 (41%)
Rxrg	XP_038947050.1	Nuc_recep-AF1	25..133	CDD:403126	21/107 (20%)
		NR_DBD_RXR	137..213	CDD:143514	47/76 (62%)
		NR_LBD_RXR_like	233..442	CDD:132741	84/210 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910