DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svp and RXRB

DIOPT Version :9

Sequence 1:	NP_001369011.1	Gene:	svp / 41491	FlyBaseID:	FBgn0003651	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001257330.1	Gene:	RXRB / 6257	HGNCID:	10478	Length:	537	Species:	Homo sapiens

Alignment Length:	562	Identity:	193/562 - (34%)
Similarity:	263/562 - (46%)	Gaps:	90/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PQSGAELSAFDIGLSRSMGLGVPP----HSAWHEPPAS-----LGGHLHAASAGPGTTTGSVATG 71
            ||..|......:|:.:.|..||..    ...|.:|.|:     .||........|| ..|....|
Human    11 PQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPG-EAGRDGMG 74

  Fly    72 GGGTTPSSVASQQSAVIKQDLSCPSLNQAGSGHHPGIKEDLSSSLPSANGGSAGGHHSGSGSGSG 136
            ..|....|..|.....:.|.:..||        .||      ..||.:...|.|          |
Human    75 DSGRDSRSPDSSSPNPLPQGVPPPS--------PPG------PPLPPSTAPSLG----------G 115

  Fly   137 SGVNPGHGSDMLPLIKGHGQDMLTSIKGQ-------PTGCGSTTPSSQANSSHS-QSSNSGSQID 193
            ||..|.......||  |....:::|..|.       |.|......|.|.||:.| ....||...|
Human   116 SGAPPPPPMPPPPL--GSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPED 178

  Fly   194 SKQNI--------------------ECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYSCRG 238
            .|..:                    .|.:|||:|||||||.::|||||.||||::|::||||||.
Human   179 VKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRD 243

  Fly   239 SRNCPIDQHHRNQCQYCRLKKCLKMGMRREAVQRGRVPPTQPGLAGMHGQYQIANGDPMGIAGFN 303
            :::|.:|:..||:|||||.:|||..||:|||||..|    |.|        :..:||..|..|..
Human   244 NKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEER----QRG--------KDKDGDGEGAGGAP 296

  Fly   304 GHSYLSSYISLLLRAEPY-------PTSRYGQCMQPNNIMGIDNICELAARLLFSAVEWAKNIPF 361
            ....:...:...|..|..       |....|....||:  .:.|||:.|.:.||:.|||||.||.
Human   297 EEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPND--PVTNICQAADKQLFTLVEWAKRIPH 359

  Fly   362 FPELQVTDQVALLRLVWSELFVLNASQCSMPLHVAPLLAAAGLHASPMAADR--VVAFMDH--IR 422
            |..|.:.|||.|||..|:||.:.:.|..|:.:... :|.|.|||....:|..  |.|..|.  .|
Human   360 FSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDG-ILLATGLHVHRNSAHSAGVGAIFDRSLSR 423

  Fly   423 IFQEQVEKLKALHVDSAEYSCLKAIVLFTTDACGLSDVTHIESLQEKSQCALEEYCRTQYPNQPT 487
            :..|.|.|::.:.:|..|..||:||:||..||.|||:.:.:|.|:||...:||.||:.:||.|..
Human   424 VLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQG 488

  Fly   488 RFGKLLLRLPSLRTVSSQVIEQLFFVRLVGKTPIETLIRDML 529
            ||.|||||||:||::..:.:|.|||.:|:|.|||:|.:.:||
Human   489 RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	45/71 (63%)
svp	NP_001369011.1	NR_LBD_COUP-TF	307..542	CDD:132746	92/234 (39%)
RXRB	NP_001257330.1	Modulating. /evidence=ECO:0000250	1..204		48/219 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..181		40/171 (23%)
		NR_DBD_RXR	204..279	CDD:143514	46/74 (62%)
		Hinge	271..295		11/35 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..299		8/34 (24%)
		NR_LBD_RXR_like	298..515	CDD:132741	84/219 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..336		4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910