Protein Alignment svp and RXRA

DIOPT Version :9

• Sequence 1: NP_001369011.1
• Gene: svp / 41491
• FlyBaseID: FBgn0003651
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_002948.1
• Gene: RXRA / 6256
• HGNCID: 10477
• Length: 462
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 180/462 - (38%)
• Similarity: 254/462 - (54%)
• Gaps: 65/462 - (14%)

  Fly   112 LSSSLPSANG-GS--AGGHHSGSGSGSGSGVNPG--HG--SDMLPLIKGHGQDMLTSIKGQPTGC 169
            ::|||.|..| ||  |...|...|.|.||   ||  |.  |.:...|.|.|...  |:...|.|.
Human    15 VNSSLTSPTGRGSMAAPSLHPSLGPGIGS---PGQLHSPISTLSSPINGMGPPF--SVISSPMGP 74

  Fly   170 GS----TTPSSQANSSHSQSSNSGSQIDSKQNIE--------------------------CVVCG 204
            .|    |||:...::...|.|:..:.:.|.::|:                          |.:||
Human    75 HSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICG 139

  Fly   205 DKSSGKHYGQFTCEGCKSFFKRSVRRNLTYSCRGSRNCPIDQHHRNQCQYCRLKKCLKMGMRREA 269
            |:|||||||.::|||||.||||:||::|||:||.:::|.||:..||:|||||.:|||.|||:|||
Human   140 DRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREA 204

  Fly   270 VQRGRVPPTQPGLAGMHGQYQ---IANGD-PMGIAGFNGHSYLSSYISLLLRAEPYPTSRYG-QC 329
            ||..|    |.|......:.:   .||.| |:       ...|.:.:::..:.|.|..:..| ..
Human   205 VQEER----QRGKDRNENEVESTSSANEDMPV-------ERILEAELAVEPKTETYVEANMGLNP 258

  Fly   330 MQPNNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSMPLH 394
            ..||:  .:.|||:.|.:.||:.|||||.||.|.||.:.|||.|||..|:||.:.:.|..|:.:.
Human   259 SSPND--PVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVK 321

  Fly   395 VAPLLAAAGLHASPMAADR--VVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTTDACGL 457
            .. :|.|.|||....:|..  |.|..|  |:..|.|.|::.:.:|..|..||:|||||..|:.||
Human   322 DG-ILLATGLHVHRNSAHSAGVGAIFD--RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGL 383

  Fly   458 SDVTHIESLQEKSQCALEEYCRTQYPNQPTRFGKLLLRLPSLRTVSSQVIEQLFFVRLVGKTPIE 522
            |:...:|:|:||...:||.||:.:||.||.||.|||||||:||::..:.:|.|||.:|:|.|||:
Human   384 SNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPID 448

  Fly   523 TLIRDML 529
            |.:.:||
Human   449 TFLMEML 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	47/71 (66%)
		NR_LBD_COUP-TF	307..542	CDD:132746	94/226 (42%)
RXRA	NP_002948.1	Modulating. /evidence=ECO:0000250	1..134		31/123 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107		30/96 (31%)
		Nuc_recep-AF1	17..126	CDD:403126	31/113 (27%)
		NR_DBD_RXR	133..209	CDD:143514	48/75 (64%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:12145331	160..165		3/4 (75%)
		Hinge	201..224		8/26 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..228		5/25 (20%)
		NR_LBD_RXR_like	229..440	CDD:132741	88/222 (40%)
		Required for nuclear export. /evidence=ECO:0000269|PubMed:15509776	348..368		6/19 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910