DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svp and rxraa

DIOPT Version :9

Sequence 1:	NP_001369011.1	Gene:	svp / 41491	FlyBaseID:	FBgn0003651	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	XP_005161240.1	Gene:	rxraa / 555578	ZFINID:	ZDB-GENE-070314-2	Length:	500	Species:	Danio rerio

Alignment Length:	582	Identity:	203/582 - (34%)
Similarity:	280/582 - (48%)	Gaps:	142/582 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCASPSTAPGFFNPR------PQSG-AE---------------LSAFDIGLSRSMGLGVP-PHSA 42
            |...|..:.||..|:      ||.| ||               ||....|...|..|..| .|..
Zfish     1 METKPFLSLGFLKPQCSLPPPPQRGRAEACTCFSGMCALHQRRLSTDCTGQVTSSPLSSPTSHRG 65

  Fly    43 WHE---PPASLG--GHLHAASAGPGTTTGSVATGGGGTTPSSVASQQSAVIKQDLSCPSLNQAGS 102
            .|.   .|.|||  |.||:    |.:|..|...|.|  :|.|       ||...:...|:...|.
Zfish    66 MHPSLLSPTSLGPSGSLHS----PISTLSSPMNGLG--SPFS-------VISSPMGPHSMASPGV 117

  Fly   103 GHHPGIKEDLSSSLPSANGGSAGGHHSGSGSGSGSGVNPGHGSDMLPLIKGHGQDMLTSIKGQPT 167
            |:.|.|...|:|.:.|.:              |...:.|       ||    |.:.:..:..||:
Zfish   118 GYGPSISPQLNSPMNSVS--------------SSEDIKP-------PL----GLNGVMKVPAQPS 157

  Fly   168 GCGSTTPSSQANSSHSQSSNSGSQIDSKQNIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNL 232
            |    ||.|.  :.|.                |.:|||:|||||||.::|||||.||||:||::|
Zfish   158 G----TPLSL--TKHI----------------CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDL 200

  Fly   233 TYSCRGSRNCPIDQHHRNQCQYCRLKKCLKMGMRRE-----AVQRGR----------VPPTQPGL 282
            ||:||.:::|.||:..||:|||||.:|||.|||:||     |||..|          |..|..
Zfish   201 TYTCRDNKDCVIDKRQRNRCQYCRYQKCLAMGMKREVLLHTAVQEERQRAKERSENEVESTSS-- 263

  Fly   283 AGMHGQYQIANGD-PMGIAGFNGHSYLSSYISLLLRAE-------PYPTSRYGQCMQPNNIMGID 339
                     ||.| |:       ...|.:.:::..:.|       |.|::      .||:  .:.
Zfish   264 ---------ANEDMPV-------EKILEAELAVEPKTETYIETNVPMPSN------SPND--PVT 304

  Fly   340 NICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSMPLHVAPLLAAAGL 404
            |||:.|.:.||:.|||||.||.|.||.:.|||.|||..|:||.:.:.|..|:.:... :|.|.||
Zfish   305 NICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDG-ILLATGL 368

  Fly   405 HASPMAADR--VVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTTDACGLSDVTHIESLQ 467
            |....:|..  |.|..|  |:..|.|.|::.:.:|..|..||:|||||..|:.|||:...:|:|:
Zfish   369 HVHRNSAHSAGVGAIFD--RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPGEVEALR 431

  Fly   468 EKSQCALEEYCRTQYPNQPTRFGKLLLRLPSLRTVSSQVIEQLFFVRLVGKTPIETLIRDML 529
            ||...:||.||:.:||.||.||.|||||||:||::..:.:|.|||.:|:|.|||:|.:.:||
Zfish   432 EKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	47/76 (62%)
svp	NP_001369011.1	NR_LBD_COUP-TF	307..542	CDD:132746	94/232 (41%)
rxraa	XP_005161240.1	Nuc_recep-AF1	63..159	CDD:288658	34/137 (25%)
		NR_DBD_RXR	166..247	CDD:143514	49/96 (51%)
		NR_LBD_RXR_like	267..478	CDD:132741	88/228 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910