DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svp and rxrb

DIOPT Version :9

Sequence 1:	NP_001369011.1	Gene:	svp / 41491	FlyBaseID:	FBgn0003651	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	XP_012823803.1	Gene:	rxrb / 548691	XenbaseID:	XB-GENE-480167	Length:	456	Species:	Xenopus tropicalis

Alignment Length:	554	Identity:	185/554 - (33%)
Similarity:	267/554 - (48%)	Gaps:	121/554 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCASPSTAPGFFNPRPQSGAELSAFDIGLSRSMGLGVPPHSAWHEPPASLGGHLHAASAGPGTTT 65
            :|.||.|               |:....|.||.....||.||          .||.:..|...|:
Frog     6 VCQSPDT---------------SSLSPPLGRSYSDTPPPPSA----------PLHPSMVGSAMTS 45

  Fly    66 GSVATGGGGTTPSSVASQQSAVIKQDLSCPSLNQAGSGHHPGIKEDLSSSLPSANGGSAGGHHSG 130
            ...:..|...:|..|           ::|    ..||   |||     ...||...|........
Frog    46 SVNSPLGSIGSPFQV-----------INC----SVGS---PGI-----PGTPSIGYGPVSSPQIN 87

  Fly   131 SGSGSGSGVNPGHGS-DMLPLIKGHGQDMLTSIKGQPTGCGSTTPSSQANSSHSQSSNSGSQIDS 194
            | :.:.||::|...| |:.|                |.|..|.       |||.    :|..:..
Frog    88 S-TVNLSGLHPVSSSEDVKP----------------PLGMRSM-------SSHP----NGGAVSG 124

  Fly   195 KQNIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYSCRGSRNCPIDQHHRNQCQYCRLKK 259
            |:  .|.:|||:|||||||.::|||||.||||::|::|||:||.:::|.:|:..||:|||||.:|
Frog   125 KR--LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYTCRDNKDCIVDKRQRNRCQYCRYQK 187

  Fly   260 CLKMGMRREAV-----------QRGRVPPTQPGLAGMHGQYQIANGDPMGIAGFNGHSYLSSYIS 313
            ||..||:||.:           |||:                    :..|.|.|:|.......:.
Frog   188 CLATGMKREVISKYSPAVQEERQRGK--------------------ERDGEAEFSGAINEEMPVE 232

  Fly   314 LLLRAEPYPTSRYGQCMQ----PNNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALL 374
            .:|.||.....:..|.::    |::  .:.|||:.|.:.||:.|||||.||.|.||.:.|||.||
Frog   233 KILEAELAVEQKSDQSLEGGGSPSD--PVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILL 295

  Fly   375 RLVWSELFVLNASQCSMPLHVAPLLAAAGLHASPMAADR--VVAFMDHIRIFQEQVEKLKALHVD 437
            |..|:||.:.:.|..|:.:... :|.|.|||....:|..  |.|..|  |:..|.|.|::.:.:|
Frog   296 RAGWNELLIASFSHRSISVKDG-ILLATGLHVHRNSAHSAGVGAIFD--RVLTELVSKMRDMRMD 357

  Fly   438 SAEYSCLKAIVLFTTDACGLSDVTHIESLQEKSQCALEEYCRTQYPNQPTRFGKLLLRLPSLRTV 502
            ..|..||:||:||..||.|||:...:|.|:||...:||.||:.:||:|..||.|||||||:||::
Frog   358 KTELGCLRAIILFNPDAKGLSNPGDVEVLREKVYASLESYCKQKYPDQQGRFAKLLLRLPALRSI 422

  Fly   503 SSQVIEQLFFVRLVGKTPIETLIRDMLLSGNSFS 536
            ..:.:|.|||.:|:|.|||:|.:.:||.:.:..|
Frog   423 GLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLS 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	42/82 (51%)
svp	NP_001369011.1	NR_LBD_COUP-TF	307..542	CDD:132746	93/236 (39%)
rxrb	XP_012823803.1	Nuc_recep-AF1	13..120	CDD:288658	37/167 (22%)
		NR_DBD_RXR	127..209	CDD:143514	42/81 (52%)
		NR_LBD_RXR_like	228..434	CDD:132741	84/210 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000