DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svp and rxrgb

DIOPT Version :9

Sequence 1:	NP_001369011.1	Gene:	svp / 41491	FlyBaseID:	FBgn0003651	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	XP_005160723.1	Gene:	rxrgb / 436617	ZFINID:	ZDB-GENE-040718-34	Length:	465	Species:	Danio rerio

Alignment Length:	501	Identity:	182/501 - (36%)
Similarity:	252/501 - (50%)	Gaps:	78/501 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PPHSAWHEPP--ASLGGHLHAASA-----GPGTTTGSVATGGGGTTPSSVASQQSAVIKQDLSCP 95
            |.:|:..:||  :|:.||....|:     .|.:|.||...|    .||..     :||...||.|
Zfish    27 PLNSSPSQPPVMSSMVGHPSVISSSRPLPSPMSTLGSSMNG----LPSPY-----SVITPSLSSP 82

  Fly    96 SLNQAGSGHHPGIKEDLSSSLPSANGGSAGGHHSGSGSGSGSGVNPGHGSDMLPLIKGHGQDMLT 160
            |:                 ||||.               ...|.|..:...|..|.....:|:..
Zfish    83 SI-----------------SLPST---------------PSMGFNTLNSPQMNSLSMNGNEDIKP 115

  Fly   161 SIKGQPTGCGSTTPSSQANSSHSQSSNSGSQIDSKQNIECVVCGDKSSGKHYGQFTCEGCKSFFK 225
            .....|.|          |.|..|.::.||.  ||.  .|.:|||:|||||||.::|||||.|||
Zfish   116 PPGLAPLG----------NMSSYQCTSPGSL--SKH--ICAICGDRSSGKHYGVYSCEGCKGFFK 166

  Fly   226 RSVRRNLTYSCRGSRNCPIDQHHRNQCQYCRLKKCLKMGMRREAVQRGRVPPTQPGLAGMHGQYQ 290
            |::|::|||:||..:.|.||:..||:|||||.:|||.|||:|||||..|    |.|......:.:
Zfish   167 RTIRKDLTYTCRDIKECLIDKRQRNRCQYCRYQKCLAMGMKREAVQEER----QRGKEKSDTEVE 227

  Fly   291 IANGDPMGIAGFNGHSYLSSYISLLLRAEPYPTSRYGQCMQPNNIMG--IDNICELAARLLFSAV 353
            ..       :.||....:...:...|..|| .|..|.: ..|:|...  :.|||..|.:.||:.|
Zfish   228 TT-------SRFNEDMPVDKILDAELSVEP-KTETYTE-SSPSNSTNDPVTNICHAADKQLFTLV 283

  Fly   354 EWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSMPLHVAPLLAAAGLHASPMAADRVVAFM 418
            ||||.||.|.:|.:.|||.|||..|:||.:.:.|..|:.:... :|...|||....:|.......
Zfish   284 EWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSITVKDG-ILLGTGLHVHRSSAHSAGVGS 347

  Fly   419 DHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTTDACGLSDVTHIESLQEKSQCALEEYCRTQYP 483
            ...|:..|.|.|:|.:.:|..|..||:|||||..||.|||:...:|:|:||...:||.|.:.:||
Zfish   348 IFNRVLTELVSKMKDMQMDKTELGCLRAIVLFNPDAKGLSNSLEVEALREKVYASLETYTKQKYP 412

  Fly   484 NQPTRFGKLLLRLPSLRTVSSQVIEQLFFVRLVGKTPIETLIRDML 529
            :||.||.|||||||:||::..:.:|.|||.:|:|.|||:|.:.:||
Zfish   413 DQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	46/71 (65%)
svp	NP_001369011.1	NR_LBD_COUP-TF	307..542	CDD:132746	91/225 (40%)
rxrgb	XP_005160723.1	Nuc_recep-AF1	30..135	CDD:288658	34/155 (22%)
		NR_DBD_RXR	139..215	CDD:143514	47/77 (61%)
		NR_LBD_RXR_like	235..443	CDD:132741	83/210 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910