DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svp and usp

DIOPT Version :9

Sequence 1:	NP_001369011.1	Gene:	svp / 41491	FlyBaseID:	FBgn0003651	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	155/520 - (29%)
Similarity:	235/520 - (45%)	Gaps:	103/520 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 ASQQSAVIKQDLSCPSLNQAGSGHHPGIKEDLSSSLPSANGGSAGGHHSGSGSGSGSGVNPGHGS 145
            ||.:.:.||:::. |.::|....::........|.:|.....|.  .|...||.|.|..|...|.
  Fly     8 ASFRLSHIKEEVK-PDISQLNDSNNSSFSPKAESPVPFMQAMSM--VHVLPGSNSASSNNNSAGD 69

  Fly   146 DMLPLIKGHGQDMLTSIKGQPTGCGSTTPSSQANSSHSQSSNSGSQIDSKQNIECVVCGDKSSGK 210
                          ..:...|...|.:..::...........|||:      ..|.:|||::|||
  Fly    70 --------------AQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSK------HLCSICGDRASGK 114

  Fly   211 HYGQFTCEGCKSFFKRSVRRNLTYSCRGSRNCPIDQHHRNQCQYCRLKKCLKMGMRREAVQR--- 272
            |||.::|||||.||||:||::|||:||.:|||.||:..||:|||||.:|||..||:|||||.
  Fly   115 HYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQ 179

  Fly   273 -------GRVPPTQPGLAG---MHGQYQIANGDPMGIAGFNG-----HSYLSSYIS--------- 313
                   ||:..:..|.:|   :.|......|...|::|..|     ..::::.:|
  Fly   180 RGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERII 244

  Fly   314 ---------------LLLRAEPYPTSRYGQCMQPNNIMGIDNICELAARLLFSAVEWAKNIPFFP 363
                           ..||..||.|      :||:....:..:|::..:.||..||:|:.:|.|.
  Fly   245 EAEQRAETQCGDRALTFLRVGPYST------VQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFA 303

  Fly   364 ELQVTDQVALLRLVWSELFVLNASQCSM-----------------------------PLHVAPLL 399
            ::.:.|||.||:..|.||.:.|.:.||:                             |..:. |.
  Fly   304 QVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLF-LN 367

  Fly   400 AAAGLHASPMAADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTTDACGLSDVTHIE 464
            .:...|.:......|.|..|  ||..|...|:|.|::|..|.||||||:|:..|..|:.....||
  Fly   368 QSFSYHRNSAIKAGVSAIFD--RILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIE 430

  Fly   465 SLQEKSQCALEEYCRTQYPNQPTRFGKLLLRLPSLRTVSSQVIEQLFFVRLVGKTPIETLIRDML 529
            ..:||....|:|:||.::|....||.:||||||:||::|.:..:.||..|:....|:|.|..:.|
  Fly   431 MCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQL 495

Fly 530 529
Fly 496 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	47/71 (66%)
svp	NP_001369011.1	NR_LBD_COUP-TF	307..542	CDD:132746	77/276 (28%)
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	48/75 (64%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	71/251 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
	3	3.010