Protein Alignment svp and Nr2e1

DIOPT Version :10

• Sequence 1: NP_001369011.1
• Gene: svp / 41491
• FlyBaseID: FBgn0003651
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_689415.1
• Gene: Nr2e1 / 21907
• MGIID: 1100526
• Length: 385
• Species: Mus musculus
• Alignment Length: 404
• Identity: 142/404 - (35%)
• Similarity: 214/404 - (52%)
• Gaps: 74/404 - (18%)

  Fly   183 SQSSNSGSQIDSKQNIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYSCRGSR--NCPID 245
            |:.:.|.|:|   .:|.|.||||:|||||||.:.|:||..|||||:|||.||.|:...  .||:|
Mouse     2 SKPAGSTSRI---LDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVD 63

  Fly   246 QHHRNQCQYCRLKKCLKMGMRREAVQRGRVPPTQPGLAGMHGQYQIANGDPMGIAGFNGHSY--- 307
            :.|||||:.|||||||::.|.::|||..|.|.|..      .:.|:|       ..|.||..
Mouse    64 KTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTST------IRKQVA-------LYFRGHKEDNG 115

  Fly   308 -----------LSSYISLLLRAEPY---------------------PTSRYGQCMQPNNIMG--- 337
                       ..::.:.:.:.||:                     ||.:|     |:.:.|
Mouse   116 AAAHFPSTALPAPAFFTAVTQLEPHGLELAAVSATPERQTLVSLAQPTPKY-----PHEVNGTPM 175

  Fly   338 ------IDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSMPLHVA 396
                  .:::||.||||||.:::|||::|.|..|.:.||:.||...|.|||||..:|.::|:...
Mouse   176 YLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN 240

  Fly   397 PLLAAAGLHASPMAADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT-------TDA 454
            .|||.:|::.....:.::...:..|:..||.|.:.:.|.:|:.|::|||.||.|.       ::.
Mouse   241 TLLAVSGMNTDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSEL 305

  Fly   455 CGLSDVTHIESLQEKSQCALEEYCRTQYPNQPTRFGKLLLRLPSLRTVSSQVIEQLFFVRLVGKT 519
            ....:...|.:||:::|..|..|..|:||.||.|||||||.||:||::|...||::||.:.:|..
Mouse   306 RSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNV 370

  Fly   520 PIETLIRDMLLSGN 533
            ||..|:.||..|.:
Mouse   371 PITRLLSDMYKSSD 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	44/73 (60%)
		NR_LBD_COUP-TF	307..542	CDD:132746	84/278 (30%)
Nr2e1	NP_689415.1	NR_DBD_TLX	8..99	CDD:143537	51/99 (52%)
		NR_LBD_Tlx_PNR_like	154..369	CDD:132748	75/219 (34%)
		Required for transcriptional repression	341..385		21/44 (48%)