DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svp and Nr2f1

DIOPT Version :9

Sequence 1:	NP_001369011.1	Gene:	svp / 41491	FlyBaseID:	FBgn0003651	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_034281.2	Gene:	Nr2f1 / 13865	MGIID:	1352451	Length:	420	Species:	Mus musculus

Alignment Length:	503	Identity:	336/503 - (66%)
Similarity:	361/503 - (71%)	Gaps:	96/503 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SAWHEPPASLGGHLHAASAGPGTTTGSVATGGGGTTPSSVASQQSAVIKQDLSCPSLNQAGSG-- 103
            |:|.:|...:.|   ....||.....:...||||       .||              |||||
Mouse     6 SSWRDPQDDVAG---GNPGGPNPAAQAARGGGGG-------EQQ--------------QAGSGAP 46

  Fly   104 HHPGIKEDLSSSLPSANGGSAGGHHSGSGSGSGSGVNPGHGSDMLPLIKGHGQDMLTSIKGQPTG 168
            |.|        ..|...|..|               .||...|     ||.|          |.|
Mouse    47 HTP--------QTPGQPGAPA---------------TPGTAGD-----KGQG----------PPG 73

  Fly   169 CGSTTPSSQANSSHSQSSNSGSQIDSKQNIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLT 233
            .|                      .|:|:||||||||||||||||||||||||||||||||||||
Mouse    74 SG----------------------QSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLT 116

  Fly   234 YSCRGSRNCPIDQHHRNQCQYCRLKKCLKMGMRREAVQRGRVPPTQPGLAGMHGQYQIANGDPMG 298
            |:||.:|||||||||||||||||||||||:|||||||||||:|||||.    .|||.:.||||:
Mouse   117 YTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPN----PGQYALTNGDPL- 176

  Fly   299 IAGFNGHSYLSSYISLLLRAEPYPTSRYG-QCMQPNNIMGIDNICELAARLLFSAVEWAKNIPFF 362
                |||.|||.||||||||||||||||| |||||||||||:|||||||||||||||||:|||||
Mouse   177 ----NGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF 237

  Fly   363 PELQVTDQVALLRLVWSELFVLNASQCSMPLHVAPLLAAAGLHASPMAADRVVAFMDHIRIFQEQ 427
            |:||:||||:||||.|||||||||:||||||||||||||||||||||:|||||||||||||||||
Mouse   238 PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQ 302

  Fly   428 VEKLKALHVDSAEYSCLKAIVLFTTDACGLSDVTHIESLQEKSQCALEEYCRTQYPNQPTRFGKL 492
            ||||||||||||||||||||||||:|||||||..||||||||||||||||.|:||||||:|||||
Mouse   303 VEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKL 367

  Fly   493 LLRLPSLRTVSSQVIEQLFFVRLVGKTPIETLIRDMLLSGNSFSWPYL 540
            ||||||||||||.|||||||||||||||||||||||||||:||:|||:
Mouse   368 LLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYM 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	67/71 (94%)
svp	NP_001369011.1	NR_LBD_COUP-TF	307..542	CDD:132746	215/235 (91%)
Nr2f1	NP_034281.2	NR_DBD_COUP_TF	83..155	CDD:143516	67/71 (94%)
		NR_LBD_COUP-TF	181..416	CDD:132746	215/235 (91%)
		Important for dimerization	341..420		68/75 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2346
eggNOG	1	0.900	-	-		E33208_3BBKC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296293at33208
OrthoFinder	1	1.000	-	-		FOG0001162
OrthoInspector	1	1.000	-	-		otm43398
orthoMCL	1	0.900	-	-		OOG6_106204
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3161
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.810