DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svp and Nr2f2

DIOPT Version :9

Sequence 1:	NP_001369011.1	Gene:	svp / 41491	FlyBaseID:	FBgn0003651	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_542956.1	Gene:	Nr2f2 / 113984	RGDID:	69305	Length:	414	Species:	Rattus norvegicus

Alignment Length:	437	Identity:	319/437 - (72%)
Similarity:	350/437 - (80%)	Gaps:	43/437 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 PGIKEDLSSSLPSANGGSAGGHHSGSGSGSGSGVNPGHGSDMLPLIKGHGQDMLTSIKGQPTGCG 170
            ||.:...:|..|...|...|..|:..        .||.|..
  Rat    16 PGSQGSQASQAPPVPGPPPGAPHTPQ--------TPGQGGP------------------------ 48

  Fly   171 STTPSSQANSSHSQSSNSGS-QIDSKQNIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY 234
            ::||:..|..|.......|| :...:|:|||||||||||||||||||||||||||||||||||:|
  Rat    49 ASTPAQTAAGSQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSY 113

  Fly   235 SCRGSRNCPIDQHHRNQCQYCRLKKCLKMGMRREAVQRGRVPPTQPGLAGMHGQYQIANGDPMGI 299
            :||.:|||||||||||||||||||||||:|||||||||||:|||||    .|||:.:.||||:
  Rat   114 TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQP----THGQFALTNGDPL-- 172

  Fly   300 AGFNGHSYLSSYISLLLRAEPYPTSRYG-QCMQPNNIMGIDNICELAARLLFSAVEWAKNIPFFP 363
               |.|||||.|||||||||||||||:| |||||||||||:||||||||:||||||||:||||||
  Rat   173 ---NCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFP 234

  Fly   364 ELQVTDQVALLRLVWSELFVLNASQCSMPLHVAPLLAAAGLHASPMAADRVVAFMDHIRIFQEQV 428
            :||:|||||||||.|||||||||:||||||||||||||||||||||:||||||||||||||||||
  Rat   235 DLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQV 299

  Fly   429 EKLKALHVDSAEYSCLKAIVLFTTDACGLSDVTHIESLQEKSQCALEEYCRTQYPNQPTRFGKLL 493
            |||||||||||||||||||||||:||||||||.|:||||||||||||||.|:|||||||||||||
  Rat   300 EKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLL 364

  Fly   494 LRLPSLRTVSSQVIEQLFFVRLVGKTPIETLIRDMLLSGNSFSWPYL 540
            |||||||||||.|||||||||||||||||||||||||||:||:|||:
  Rat   365 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYM 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svp	NP_001369011.1	NR_DBD_COUP_TF	200..272	CDD:143516	66/71 (93%)
svp	NP_001369011.1	NR_LBD_COUP-TF	307..542	CDD:132746	215/235 (91%)
Nr2f2	NP_542956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72		16/87 (18%)
		NR_DBD_COUP_TF	79..151	CDD:143516	66/71 (93%)
		Interaction with ZFPM2. /evidence=ECO:0000250	117..414		264/304 (87%)
		NR_LBD_COUP-TF	177..411	CDD:132746	214/233 (92%)
		Important for dimerization	337..414		69/75 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2283
eggNOG	1	0.900	-	-		E33208_3BBKC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7628
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296293at33208
OrthoFinder	1	1.000	-	-		FOG0001162
OrthoInspector	1	1.000	-	-		otm45468
orthoMCL	1	0.900	-	-		OOG6_106204
Panther	1	1.100	-	-	O	PTHR24083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.780