DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3942 and GDE1

DIOPT Version :9

Sequence 1:	NP_650171.2	Gene:	CG3942 / 41489	FlyBaseID:	FBgn0038008	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_015215.1	Gene:	GDE1 / 855994	SGDID:	S000006031	Length:	1223	Species:	Saccharomyces cerevisiae

Alignment Length:	398	Identity:	116/398 - (29%)
Similarity:	158/398 - (39%)	Gaps:	46/398 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 GSARVKITCASTHRPLMEMCVRYLIIRPLPNFRCDLSHSYERYWRKNRLCMNIGHKGSGNTYRLG 382
            ||..|.|....|...|..:...|:||.|..:.:..|..: |.||:.......|||:|.|......
Yeast   824 GSVTVPIIANHTLEILGTLKFEYIIITPFEHPQLPLERT-ETYWKSLVSTRVIGHRGLGKNNPNK 887

  Fly   383 SDVVRENTLYGFKQAVLANADMVEMDVQLTQDAQVVVYHDFVLRFMLQRMPSFEDLLEN-QDLLI 446
            |..:.|||:..|..|....|..||.|||||:|...||||||::......:|..|..||. .||
Yeast   888 SLQIGENTVESFIMAASLGASYVEFDVQLTKDNVPVVYHDFLVAETGVDIPMHELTLEQFLDL-- 950

  Fly   447 FAYENLNKLMLLAMGGS-----KRKDLIAVPLEAFSYDQLKEVKVLRFA----------GSKGCD 496
               .|.:|..:....|.     ...|.........|.|. .:|..||.|          .|....
Yeast   951 ---NNADKEHIQRGAGHSPHHVNGADTALQKYRGRSVDD-SDVSTLRRAWDLHDNDPNGKSNNAH 1011

  Fly   497 KSCDRMLLEQ-----------------RPFPLLLDLLDEENLPVDMGFLIEIKWPQMTNMRRWES 544
            .|.:||.|.:                 ..|..|.:|.  :.:|.::||.||.|:|.:......|.
Yeast  1012 WSDNRMRLTKTFKKNNFKGNARGHSIASSFVTLKELF--KKIPANVGFNIECKFPMLDEAEEEEL 1074

  Fly   545 GSFKPTFDRNFYVDTILEIVLNKAGKRRIVFCSFDADICAMVRFKQNVYPVTLLLEDPHSPVQYA 609
            |..  ..:.|.:|||:|::|.:.|..|.|:|.||..|||.|:..||.|.|:..|.|.  ...|.|
Yeast  1075 GQI--MMEMNHWVDTVLKVVFDNANGRDIIFSSFHPDICIMLSLKQPVIPILFLTEG--GSEQMA 1135

  Fly   610 DQRVSVQDVAVRFCNSLEFLGLTLHANSLLNKPSTMAYLHQINLDAFVYGSSTIDLEIRNKLKKH 674
            |.|.|.....:||......||:...|..:|..|..:..:....|....||....|.|..:...:.
Yeast  1136 DLRASSLQNGIRFAKKWNLLGIVSAAAPILKAPRLVQVVKSNGLVCVTYGVDNNDPENASIQIEA 1200

  Fly   675 GVLGIIYD 682
            ||..:|.|
Yeast  1201 GVDAVIVD 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3942	NP_650171.2	CBM20_Prei4	44..164	CDD:99888
		GDPD_GDE5	368..684	CDD:176549	102/348 (29%)
		GDPD	372..685	CDD:281062	100/344 (29%)
GDE1	NP_015215.1	COG5408	1..300	CDD:227695
		ANKYR	361..594	CDD:223738
		ANK repeat	427..466	CDD:293786
		ANK repeat	468..501	CDD:293786
		ANK repeat	506..535	CDD:293786
		Ank_2	508..603	CDD:403870
		ANK repeat	540..569	CDD:293786
		ANK repeat	572..603	CDD:293786
		GDPD_YPL110cp_fungi	871..1219	CDD:176548	102/350 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0584
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3769
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001717
OrthoInspector	1	1.000	-	-		otm46500
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1268
TreeFam	1	0.960	-	-
	9	8.750