DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3942 and gpcpd1

DIOPT Version :9

Sequence 1:	NP_650171.2	Gene:	CG3942 / 41489	FlyBaseID:	FBgn0038008	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_021324084.1	Gene:	gpcpd1 / 492483	ZFINID:	ZDB-GENE-060503-472	Length:	727	Species:	Danio rerio

Alignment Length:	719	Identity:	185/719 - (25%)
Similarity:	300/719 - (41%)	Gaps:	153/719 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 EYVAISGNCPSLGNWDPKEVYILAKNDCISCLCNCRQFEASLEIPRNIDIHYRY--CVVIHDPET 118
            |.:|:.|:|.:||:|..::...|...:....|     :..::.:||..:..|||  ..::.....
Zfish    79 EVIAVVGSCETLGSWCQQKAVTLQPAEEDGTL-----WRTTIHVPRGAETKYRYFKAFILESKNA 138

  Fly   119 D---EVYIRFWESQLYPRVIRTCQNMLKNCDVFGKPHDDDEANQVDRGWATTETIVHLKI---FN 177
            .   :|.:..||:...||.:...:..|...|.....||..|.  ||.||.|.:|.:.|::   ..
Zfish   139 GGPCQVIVNRWETHQLPRSLSPSEPELVVDDGHFGVHDGAEC--VDSGWLTCQTEIRLRLHYSVK 201

  Fly   178 APFCWQRQKPRLLYVHVQPMFEVPENPCNEPANPIKMVSSQTRLSRYLSTREIKAGNQYLQLAQV 242
            .|....::|.:.....::.|.|..|....|..:|    ||..:::..|....|.......:.:|.
Zfish   202 PPVSITKKKFKTSRFRLKLMLEGVEEEEEEEESP----SSWHKMTTTLEMSMISDDGYKSRHSQP 262

  Fly   243 EVTNLCVQNALAAQQRFGARCG-----------------PKDMELFHCSIAFPEETLYRLDLYTY 290
            |                   ||                 |.::.|   :..|.||.|....:...
Zfish   263 E-------------------CGYALEPSRWTEYTIHTMDPDNLVL---TFEFFEEDLSETVVQGD 305

  Fly   291 AHKAGYDEPPYHYGYGFLMPDQLL--GTE-GSARVKITCASTHRPLMEMCVRYLIIRPLPNFRCD 352
            ||       |.|.|...|:....:  |.: |...:.|...::.:.|.::.|.||:.||:...:||
Zfish   306 AH-------PGHVGTACLLSSSFVESGKDLGVVTLPIMSRNSRQTLGKVRVDYLVTRPIQGLQCD 363

  Fly   353 LSHSYERYWRKNRLCMNIGHKGSGNTYRLGSDVVRENTLYGFKQAVLANADMVEMDVQLTQDAQV 417
            :|.|:.:|||| |..:::||:|:|:|:......:||||:..|..|....|..||.||.|::|...
Zfish   364 MSRSFTKYWRK-RSALDVGHRGAGSTHAAKHHKIRENTIASFLSAANHGAAYVEFDVHLSKDLVP 427

  Fly   418 VVYHDFVLRFMLQRMPSFEDLLENQDLLIFAYENLNKLMLLAMGGSKRKD-----LIAVPLEAFS 477
            |||||                                 :...:...|:.|     |..||::..:
Zfish   428 VVYHD---------------------------------LTCCISTKKKNDKTSMLLFEVPVKDLT 459

  Fly   478 YDQLKEVKVLRFAGSKGCD-------KSCDRMLLEQRPFPLLLDLLDEENLPVDMGFLIEIKWPQ 535
            :|||   ::|:.|.:...|       :..:..:.|.:|||.|..:.  :::|.::||.||:||..
Zfish   460 FDQL---QLLKLAHTTALDTHDHKDLQDEEEYIDEHQPFPSLPQIF--QSVPENVGFNIELKWIS 519

  Fly   536 MTNMRRWESGSFKPTFDRNFYVDTILEIVLNKAGKRRIVFCSFDADICAMVRFKQNVYPVTLLLE 600
            ......|:: :....|:.|.::|.||..||..||.|||:|..||.|:|.|||.|||.||:..|.:
Zfish   520 QFKDGSWDA-NLSTYFNMNQFLDIILTCVLQNAGNRRIIFSCFDPDVCTMVRQKQNKYPILFLTQ 583

  Fly   601 D-----PHSPVQYADQRVSVQDVAVRFCNSLEFLGLTLHANSLLNKPSTMAYLHQINLDAFVYGS 660
            .     |    :..|.|.....:|:.|..|...||::.|.:.||.....:.......|..|.:|.
Zfish   584 GVTQLYP----ELMDIRCQSTKIAMSFAQSENILGISAHTDELLKNMEFIGEAQSKGLVVFCWGD 644

  Fly   661 STIDLEIRNKLKKHGVLGIIYDRL--DQLDQVG----EELEGDTMCTIDSVTTRRVIQETEVEEW 719
            ...|.|.|.||::||:.|:||||:  |:|:|..    ||..|:                  ::|.
Zfish   645 YNNDHENRRKLREHGIDGLIYDRICEDKLEQSNIFKMEEQGGN------------------LKEV 691

  Fly   720 IQKC 723
            ||.|
Zfish   692 IQTC 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3942	NP_650171.2	CBM20_Prei4	44..164	CDD:99888	26/112 (23%)
		GDPD_GDE5	368..684	CDD:176549	98/332 (30%)
		GDPD	372..685	CDD:281062	98/331 (30%)
gpcpd1	XP_021324084.1	CBM20_Prei4	65..186	CDD:99888	27/113 (24%)
gpcpd1	XP_021324084.1	GDPD_GDE5	378..668	CDD:176549	98/332 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596782
Domainoid	1	1.000	59	1.000	Domainoid score	I10647
eggNOG	1	0.900	-	-		E1_COG0584
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10478
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D184242at33208
OrthoFinder	1	1.000	-	-		FOG0001717
OrthoInspector	1	1.000	-	-		otm25676
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1268
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.810