DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3942 and Gpcpd1

DIOPT Version :9

Sequence 1:	NP_650171.2	Gene:	CG3942 / 41489	FlyBaseID:	FBgn0038008	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_038961393.1	Gene:	Gpcpd1 / 362219	RGDID:	735140	Length:	679	Species:	Rattus norvegicus

Alignment Length:	733	Identity:	208/733 - (28%)
Similarity:	328/733 - (44%)	Gaps:	151/733 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PFCVVF--HSSLNGNEYVAISGNCPSLGNWDPKEVYILAKNDCISCLCNCRQFEASLEIPRNIDI 105
            |..|.|  ..:|...|..|:.|||.:||||.|:....|.:::....:     ::|.:.:.|.:.:
  Rat     3 PSQVTFEIRGTLLPGEVFAMCGNCDALGNWSPQNAVPLTESETGESV-----WKAVIVLSRGMSV 62

  Fly   106 HYRY---CVVIHDPET----DEVYIRFWESQLYPRVIRTCQN-MLKNCDVFGKPHDDDEANQVDR 162
            .|||   |.:  :|:|    .:|.:..||:.|.||.|...:| ::.:...|| .|:..|.  :|.
  Rat    63 KYRYFRGCFL--EPKTIGGPCQVIVHKWETHLQPRSITPLENEIIIDDGQFG-IHNGVET--LDS 122

  Fly   163 GWATTETIVHLKIFNAPFCWQRQKPRLLYVHVQPMFEVPENPCNEPANPIKMVSSQTRLSRY--- 224
            ||.|.:|.:.|::..:      :||                       |:.:...:.:.||:
  Rat   123 GWLTCQTEIRLRLHFS------EKP-----------------------PVSITKKKFKKSRFRVK 158

  Fly   225 LSTREI--------KAGNQYLQLAQVEVTNLCVQNALAAQQRFGAR-----CG------------ 264
            |:...:        ||....|.    :::| .::.:|.:...|..|     ||
  Rat   159 LTLEGLEEDDDDDDKASPTVLH----KMSN-SLEISLISDNEFKCRHSQPECGYGLQPDRWTEYS 218

  Fly   265 -----PKDMELFHCSIAFPEETLYRLDLYTYAHKAGYDEPPYHYGYGFLMPDQLLGTEGSARV-- 322
                 |.::||.   ..|.||.|..       |....|..|.|.|...|:...:..:|.||.:
  Rat   219 IQTMEPDNLELI---FDFFEEDLSE-------HVVQGDVLPGHVGTACLLSSTIAESERSAGILT 273

  Fly   323 -KITCASTHRPLMEMCVRYLIIRPLPNFRCDLSHSYERYWRKNRLCMNIGHKGSGN---TYRLGS 383
             .|...|:.:.:.::.|.::||:|||.:.|.:..|:.:|| |.|:.:::||:|:||   |.:|..
  Rat   274 LPIMSRSSRKTIGKVRVDFIIIKPLPGYSCSMQSSFSKYW-KPRIPLDVGHRGAGNSTTTAKLAK 337

  Fly   384 DVVRENTLYGFKQAVLANADMVEMDVQLTQDAQVVVYHDFVLRFMLQRMPSFEDLLENQDLLIFA 448
              |:|||:...:.|....|..||.||.|::|...|||||......::|    :..:..|     .
  Rat   338 --VQENTIASLRNAASHGAAFVEFDVHLSKDLVPVVYHDLTCCLTMKR----KKFVHTQ-----K 391

  Fly   449 YENLNKLMLLAMGGSKRKDLIAVPLEAFSYDQLKEVKV-----LRFAGSKGCDKSCDRMLLEQRP 508
            ||            :...:|..:|::..::|||:.:|:     |:....|.|....:....|.:|
  Rat   392 YE------------ADPVELFEIPVKELTFDQLQLLKLSHVTALKTKDQKQCMAEEENSFSENQP 444

  Fly   509 FPLLLDLLDEENLPVDMGFLIEIKWPQMTNMRRWESGSFKPTFDRNFYVDTILEIVLNKAGKRRI 573
            ||.|..:|  |:||.::||.|||||........|: |:....||.|.::|.||:.||..:|||||
  Rat   445 FPSLKMVL--ESLPENVGFNIEIKWICQHRDGVWD-GNLSTYFDMNAFLDIILKTVLENSGKRRI 506

  Fly   574 VFCSFDADICAMVRFKQNVYPVTLLLEDPHSPV--QYADQRVSVQDVAVRFCNSLEFLGLTLHAN 636
            ||.|||||||.|||.|||.||: |.|....|.:  :..|.|.....:|:.|......||:..|..
  Rat   507 VFSSFDADICTMVRQKQNKYPI-LFLTQGKSDIYPELMDLRSRTTPIAMSFAQFENILGINAHTE 570

  Fly   637 SLLNKPSTMAYLHQINLDAFVYGSSTIDLEIRNKLKKHGVLGIIYDRL-------------DQLD 688
            .||..||.:.......|..|.:|..|.|.|.|.|||:.||.|:||||:             :||:
  Rat   571 DLLRNPSYVQEAKDKGLVIFCWGDDTNDPENRRKLKEFGVNGLIYDRIYDWMPEQPNIFQVEQLE 635

  Fly   689 QVGEELEGDTMCTIDSVT 706
            ::..||.....|...:|:
  Rat   636 RLKRELPELKNCLCPTVS 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3942	NP_650171.2	CBM20_Prei4	44..164	CDD:99888	35/129 (27%)
		GDPD_GDE5	368..684	CDD:176549	115/325 (35%)
		GDPD	372..685	CDD:281062	115/335 (34%)
Gpcpd1	XP_038961393.1	CBM20_Prei4	4..125	CDD:99888	36/130 (28%)
Gpcpd1	XP_038961393.1	GDPD_GDE5	319..618	CDD:176549	115/325 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354471
Domainoid	1	1.000	71	1.000	Domainoid score	I9232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10478
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D184242at33208
OrthoFinder	1	1.000	-	-		FOG0001717
OrthoInspector	1	1.000	-	-		otm45364
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22958
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1268
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.950