DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3942 and CG2818

DIOPT Version :9

Sequence 1:	NP_650171.2	Gene:	CG3942 / 41489	FlyBaseID:	FBgn0038008	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_608804.1	Gene:	CG2818 / 33597	FlyBaseID:	FBgn0031566	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	716	Identity:	255/716 - (35%)
Similarity:	370/716 - (51%)	Gaps:	83/716 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHRWFFANEREECERKPEEDGPSSA---SETQEPPPPPPVPTTE-WPFCVVFHSSLNGNEYVAIS 61
            ||.|..::..:|.........|:|:   |..:.......:.|.. |.|.|:.:..|..||.:||.
  Fly     1 MHNWLASHNGDEDAMAAPSSCPASSENGSRLESRRIFGDITTNRLWTFRVLMNQDLAPNEQLAIV 65

  Fly    62 GNCPSLGNWDPKEVYILAKNDCISCLCNCRQFEASLEIPRNIDIHYRYCVVIHDPETDEVYIRFW 126
            |||.:||||......||:||:..:...|.  :...:.|||:.|..|||.|...||.|:::.:|.|
  Fly    66 GNCEALGNWQHSGAAILSKNEEDNEYSNL--WTGEIYIPRHCDTEYRYMVCAVDPGTEQLIVRRW 128

  Fly   127 ESQLYPRVIRTC-QNMLKN-CDVFGKPHDDDEANQVDRGWATTETIVHLKIFNAPFCW-QRQKPR 188
            |:||.||:::.. :...|| .|:||..:..:   :|||||.|.||:|.||.|.|||.: ||.|.|
  Fly   129 ETQLQPRIVKELDEQPAKNQSDIFGSFNGQE---KVDRGWLTKETLVQLKFFYAPFTFKQRMKRR 190

  Fly   189 LLYVHVQPM-FEVPENPCNE--PANPIK-MVSSQTRLSRYLSTREIKAGNQYLQLAQVEVTNLCV 249
            .:.|.|.|| ..:|...|:.  |::|:: .:|:.|.     .|:| ..|......|..||..|..
  Fly   191 HIQVKVTPMNLSIPSAGCDTMLPSSPMEDSLSNDTH-----DTKE-NGGESSTAFAFSEVVTLSA 249

  Fly   250 QNA-LAAQQRFGARCGPKDMELFHCSIAFPEETLYRLDLYTYAHK-AGYDEPPYHYGYGFLMPDQ 312
            ... :.:|::||..|||.|:.:||.::...|.|.|.:|||:|:.: |..|.||.|.||.:::|:.
  Fly   250 DECEIRSQEQFGTGCGPTDLVIFHLTVGDFENTAYLIDLYSYSSRVAKEDGPPNHLGYHYVLPNL 314

  Fly   313 LLGTEGSARVKITCASTHRPLMEMCVRYLIIRPLPNFRC---DLSHSYERYWRKNRLCMNIGHKG 374
            ...:||:..:.||||..||||..|.:.|||::  |:..|   |:|.||.|||......:::||:|
  Fly   315 FKRSEGNLELPITCAKGHRPLGMMRLGYLIVK--PSSLCALMDMSVSYARYWNSKWTGLDVGHRG 377

  Fly   375 SGNTYRLGSDVVRENTLYGFKQAVLANADMVEMDVQLTQDAQVVVYHDFVLRFMLQRMPSFEDLL 439
            ||.:::....|:||||:...|.|....|||||.||||::|...||||||::...|:...|.::
  Fly   378 SGTSFKAKDAVIRENTITSLKNAAEHGADMVEFDVQLSKDLVPVVYHDFMIYVSLKSKCSLQE-- 440

  Fly   440 ENQDLLIFAYENLNKLMLLAMGGSKRKDLIAVPLEAFSYDQLKEVKVLRFAGSKGCDK------- 497
                                      .|.:|:|:...|.:|||::||...|  :|..:
  Fly   441 --------------------------HDFLALPMRELSLEQLKKLKVYHIA--EGLSRETRSFHN 477

  Fly   498 -SCDRMLLEQRPFPLLLDLLDEENLPVDMGFLIEIKWPQMTNMRRWESGSFKPTF----DRNFYV 557
             .|    ||.:|||.|.|:||.  |.|.:||.|||||.|     |.|.|..:..|    |||.|:
  Fly   478 DDC----LEHQPFPQLCDVLDA--LDVHVGFNIEIKWSQ-----RLEDGKMEEEFEHVVDRNLYI 531

  Fly   558 DTILEIVLNKAGKRRIVFCSFDADICAMVRFKQNVYPVTLLLEDPHSPVQ-YADQRVSVQDVAVR 621
            |.||:::|.|||.||||...||.|||.::|||||.|||..|.....:..| |.|.|.:..::||.
  Fly   532 DCILDVILRKAGNRRIVLSCFDPDICTILRFKQNRYPVMFLTLGRTTKYQKYMDPRGNSMELAVW 596

  Fly   622 FCNSLEFLGLTLHANSLLNKPSTMAYLHQINLDAFVYGSSTIDLEIRNKLKKHGVLGIIYDRLDQ 686
            ...::||||:..|...||..||.:....:..|..|.:|......:....||:.|:..||||::|.
  Fly   597 HAVAMEFLGVVAHTEDLLRDPSQVNLAKERGLVLFCWGDDNNSKDTIKLLKELGLHAIIYDKMDV 661

  Fly   687 L 687
            |
  Fly   662 L 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3942	NP_650171.2	CBM20_Prei4	44..164	CDD:99888	45/121 (37%)
		GDPD_GDE5	368..684	CDD:176549	119/328 (36%)
		GDPD	372..685	CDD:281062	118/325 (36%)
CG2818	NP_608804.1	CBM20_Prei4	44..166	CDD:99888	47/126 (37%)
		GDPD_GDE5	371..659	CDD:176549	119/328 (36%)
		GDPD	375..661	CDD:281062	118/326 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473135
Domainoid	1	1.000	104	1.000	Domainoid score	I2222
eggNOG	1	0.900	-	-		E1_COG0584
Homologene	1	1.000	-	-		H10478
Inparanoid	1	1.050	311	1.000	Inparanoid score	I1548
Isobase	1	0.950	-	0	Normalized mean entropy	S3769
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D184242at33208
OrthoFinder	1	1.000	-	-		FOG0001717
OrthoInspector	1	1.000	-	-		otm25676
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1268
	12	11.850