DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3942 and gpcp-1

DIOPT Version :9

Sequence 1:	NP_650171.2	Gene:	CG3942 / 41489	FlyBaseID:	FBgn0038008	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001256998.1	Gene:	gpcp-1 / 180600	WormBaseID:	WBGene00019612	Length:	690	Species:	Caenorhabditis elegans

Alignment Length:	705	Identity:	184/705 - (26%)
Similarity:	305/705 - (43%)	Gaps:	124/705 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VFHSSLNGNEYVAISGNCPSLGNWDPKEVYILAKNDCISCLCNCRQFEASLEIPRNI-DIHYRYC 110
            ||.|.:...|.:.:.|:.|.||.|:|::.:.|.|:....     ..|.|.:.:|.:| :.::||.
Worm    11 VFCSEVREWEKIHVVGSLPVLGEWNPRKSFPLTKSTDEE-----NTFHAIVSVPSSIKEFNFRYI 70

  Fly   111 VVIH-DP---ETDE--VYIRFWESQLYPRVIRTCQNMLKNCDVFGKPHDDDE------ANQVDRG 163
            .|:: ||   .|.|  :.:..||:.   ...|||...:::.|...:.:..|:      ..|:..|
Worm    71 RVMYLDPSENNTSEPIMVLSKWETF---NNARTCLIGVESQDGVARKNITDQFGSYSGKTQITDG 132

  Fly   164 WATT--ETIVH-------LKIFNAPFCWQ--RQKPRLLYVHVQPMFEVPENPCNEPANPIKMVSS 217
            |...  |::|:       ||.|...:..:  |.|.....|....||....          |.::.
Worm   133 WILNEKESVVYFRIHGEALKFFAKSYANKEYRLKVEPFDVRYSEMFSYTR----------KDITD 187

  Fly   218 QTRLSRYLSTREIKA--GNQYLQL--------AQVEVTNLCVQNALAAQQRFGARCGPKDME--L 270
            :..:.|:.|.....:  |:..:.|        :..:::.|..::.:...|.|.......|.:  :
Worm   188 RRGVWRHSSVYASMSIDGDDVVNLPTPSLPCFSNTDLSVLTREDPIFGDQYFNGSVFRNDQDYLV 252

  Fly   271 FHCSIAFPEETLYRLDLYTYAHKAGYDEPPYHYGYGFLMPDQLLGTEGSARVKITCASTHRPLME 335
            |.......:...:|::.| :..|        .....:::|..:.||.| |.|......:..|:..
Worm   253 FRTRTVSLQNLAFRIEFY-HGEK--------RCALSYVLPSSMSGTHG-ATVSPVIGLSSAPVGH 307

  Fly   336 MCVRYLIIR----PLPNFRCD-LSHSYERYWRKNRLCMNIGHKGSGNTY--RLGSDVVRENTLYG 393
            :.|.|:|::    ...|...| :..::.|||||....:.|||:|.|::|  .:|.   ||||::.
Worm   308 INVNYMIVKRNKYTDQNLDIDSMKTTFGRYWRKRNRMLQIGHRGMGSSYTKNIGQ---RENTIFS 369

  Fly   394 FKQAVLANADMVEMDVQLTQDAQVVVYHDF-VLRFMLQR-MPSFEDLL--ENQDLLIFAYENLN- 453
            ..:|....||.||||||||:|.:.|||||| ||..:..| .||.....  ||:.|...|.::|.
Worm   370 LNEAARRGADYVEMDVQLTKDLKTVVYHDFHVLVAVAGRDSPSSTPTAAGENKSLHEIAIKDLTL 434

  Fly   454 -KLMLL------AMGGSKRKDLIAVPLEAFSYDQLKEVKVLRFAGSKGCDKSCDRMLLEQRPFPL 511
             :|.||      ...||..:..:|:.:.. |..:..|:.|                     |||.
Worm   435 AQLNLLHFEHISRANGSSAESPVALSVTP-SKTETDELHV---------------------PFPS 477

  Fly   512 LLDLLDEENLPVDMGFLIEIKWPQMTNMRRWESGSFKPTFDRNFYVDTILEIVLNKAGKRRIVFC 576
            |..:|  .::..::|..||||:|........|...:   |::|.:||.||..|...||.|||:|.
Worm   478 LAQVL--RHVDENVGLNIEIKYPMYMQDGSHECQGY---FEQNKFVDIILAEVAEHAGNRRIIFS 537

  Fly   577 SFDADICAMVRFKQNVYPVTLLL---EDPHSPVQYADQRVSVQDVAVRFCNSLEFLGLTLHANSL 638
            .|:.|||.|:..||:.|||:.|:   .:.:.|.|  |.|.....:|..|....|.||:..|:..|
Worm   538 CFEPDICTMITKKQHKYPVSFLVVGATNRYMPFQ--DIRSDCSKIAANFAAGCELLGVNFHSEEL 600

  Fly   639 L--NKPSTMAYLHQINLDAFVYGSSTIDLEIRNKLK-KHGVLGIIYDRLDQLDQV 690
            |  .||..:|  .:..|..||:|......|::...: :..|.|:|:||:.: |:|
Worm   601 LIDQKPIEIA--EKYGLIKFVWGDDLNSKEVQKHFRDEMNVDGLIFDRIGE-DEV 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3942	NP_650171.2	CBM20_Prei4	44..164	CDD:99888	31/129 (24%)
		GDPD_GDE5	368..684	CDD:176549	108/335 (32%)
		GDPD	372..685	CDD:281062	107/332 (32%)
gpcp-1	NP_001256998.1	CBM20_Prei4	5..134	CDD:99888	32/130 (25%)
		GDPD_GDE5	345..647	CDD:176549	108/335 (32%)
		GDPD	349..649	CDD:281062	107/333 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I6915
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I1548
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28688
OrthoDB	1	1.010	-	-		D184242at33208
OrthoFinder	1	1.000	-	-		FOG0001717
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1268
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.080