Protein Alignment Cyp313a3 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_650170.2
• Gene: Cyp313a3 / 41488
• FlyBaseID: FBgn0038007
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 140/523 - (26%)
• Similarity: 214/523 - (40%)
• Gaps: 114/523 - (21%)

  Fly     6 LLLAVG------VCFWIYFLWSR-RRLYMMHFKIP-------GPMGLPILGIAFEYLITYKRKMS 56
            |||.||      :..|.|..::. |||..  |..|       |.:||         :...:..:.
Human    22 LLLVVGSWLLARILAWTYAFYNNCRRLQC--FPQPPKRNWFWGHLGL---------ITPTEEGLK 75

  Fly    57 IRTKYMDIYGSTCLVWVGP-TPFVITRDPKIAEEIF-LSPECLNRSSIFSKPVNSCTGDGLLSLE 119
            ..|:....|.....||:|| .||::...|.....|. .|.....:.::|.:.:....|:|:|...
Human    76 NSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSG 140

  Fly   120 ASKWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKV----------RDDIVR 174
            ..||...|:.|.|||..|:|.|::.|||..|..::.....|..:|..::          .|.:.:
Human   141 GDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQK 205

  Fly   175 WSFR------------IATQTTVGTDVKKDASFKNDSVLKSYETFMKIIVMNVLLPFTHN----- 222
            ..|.            |||...:...|:|    ::..:|:.         |:.|...:|:
Human   206 CIFSFDSHCQERPSEYIATILELSALVEK----RSQHILQH---------MDFLYYLSHDGRRFH 257

  Fly   223 ------------------KIFSTLGGFETQKALAKSNVNKMIGTIVDKKLMTKPESGSQPEITSV 269
                              :...|.|..:..|..|||.....|    |..|::|.|.|
Human   258 RACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFI----DVLLLSKDEDG-------- 310

  Fly   270 INKAIELHRNGEMSREEVQSECCSFVVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVA 334
              ||        :|.|::::|..:|:....:||...:...|..||..||:|:...||::||....
Human   311 --KA--------LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDR 365

  Fly   335 GDFEVTYDDLQRMVFLERVVNETLRLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRN 399
            ...|:.:|||.::.||...|.|:|||.|..||..|...:|..|..|.|||||:...|||...|.|
Human   366 DPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHN 430

  Fly   400 RDHWGTDPSSFNPDHFLPDNVRDRHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCKVSTS 464
            ...| .||..::|..|.|:|.:.|.|.|:||||.|.|||||..:.:...|:.|:.:|.:
Human   431 PTVW-PDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLH------ 488

  Fly   465 FRY 467
            ||:
Human   489 FRF 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	CYP313-like	66..487	CDD:410680	123/449 (27%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	125/460 (27%)