DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a3 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	546	Identity:	143/546 - (26%)
Similarity:	244/546 - (44%)	Gaps:	100/546 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VGVCFWIYFL--------------------------WSRRRLYMMHFKIPGPMG-LPILGIAFEY 47
            :|:.|.:|.|                          |:..|      .|||..| .||:|.|.::
Zfish     1 MGILFGLYILGILFTAVLLLLLASTAYNPLKNYIGKWNEMR------PIPGMAGAYPIIGNALQF 59

  Fly    48 LITYKRKMSIRTKYMDIYGS------------TCLVWVGPTPFVITRDPKIAEEIFLSPECLNRS 100
                      :|...|.:..            ...|||||.||:|....:..|.:..:...|::|
Zfish    60 ----------KTNAGDFFNQIIEGTNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKS 114

  Fly   101 SIFSKPVNSCTGDGLLSLEASKWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGE 165
            ..: :.::...|.|||:....||.:|||.|.|.|..::|..||.:.|.:...|:        |..
Zfish   115 YSY-RFLHPWLGTGLLTSTGEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILI--------QKM 170

  Fly   166 KKVRDD--------IVRWSFRIATQTTVGTDVKKDASFKNDSVLKSYETFMKIIVMNVLLP---- 218
            :|:.|.        |...:..|..:|.:|..:...::..::.|...|: ...||......|
Zfish   171 QKLEDGEPFNCFNFITLCALDIICETAMGKKIYAQSNADSEYVQSVYK-MSDIITKRQRAPWLWP 234

  Fly   219 -FTHNKIFSTLGGFETQKALAKSNVNKMIGTIVDKK---LMTKPESGS-------QPEITSVINK 272
             :.:||:..   |.|..|.|  ..::.....::.::   :.::|:|.|       |..:..::..
Zfish   235 DWIYNKLKE---GKEHAKRL--KILHSFTANVIRERAEFMSSEPDSDSDQGERKRQAFLDMLLKT 294

  Fly   273 AIELHRNGE-MSREEVQSECCSFVVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGD 336
            ..|   ||: :|.|::|.|..:|:....:||..::..||.|:...||.|..|..||:|:|. :.:
Zfish   295 TYE---NGQKLSHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFG-SSE 355

  Fly   337 FEVTYDDLQRMVFLERVVNETLRLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRD 401
            ..|..:||:::.:||.|:.|:||:.||||...|.......: :|..:||||...|..:|.||:..
Zfish   356 RHVGVEDLKKLRYLECVIKESLRIFPSVPLFARSICEACHI-NGFKVPKGVNAVIIPYALHRDPR 419

  Fly   402 HWGTDPSSFNPDHFLPDNVRDRHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCKVSTSFR 466
            :: .:|..|.|:.|:|:|.:.||||||||||.|.|||||.::.:|..|:.|:.|||:..|.....
Zfish   420 YF-PEPEEFQPERFMPENSKGRHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQS 483

  Fly   467 YEDLEFVDNIGMELAQSPGLEFHRRT 492
            .|:|..:..:.:...:...::..||:
Zfish   484 REELRPLGELILRPEKGIWIKLQRRS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	132/466 (28%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	134/491 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910