DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a3 and cyp46a1.1

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001018358.1	Gene:	cyp46a1.1 / 553543	ZFINID:	ZDB-GENE-050522-464	Length:	501	Species:	Danio rerio

Alignment Length:	502	Identity:	123/502 - (24%)
Similarity:	225/502 - (44%)	Gaps:	65/502 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FQLLLAV-----GVCFWIYFLWSRRRLYMMHFKIPGPMGLP----ILG--------IAFEYLITY 51
            |.||.||     |.|.:|:      .|:..:..||||   |    :||        :..:..:.:
Zfish    11 FFLLAAVFTAFLGYCLYIH------HLHQKYDHIPGP---PRDSFLLGHSSSLTKAVYSDNNLIH 66

  Fly    52 KRKMSIRTKYMDIYGSTCLVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSKPVN----SCTG 112
            ...:....||..:|....|.:|    .::...|:..:.|.:||:.:....::.:..|    ...|
Zfish    67 DLFLHWAEKYGPVYRINTLHYV----TIMVYCPEATKTIMMSPKYIKDPFVYKQLFNLFGKRFLG 127

  Fly   113 DGLL-SLEASKWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDIVRW- 175
            :||: :::...|..:|:.::|||....|.|.:..|:..::.|:..|:.:.......|..|:|..
Zfish   128 NGLITAVDHDMWYRQRRIMDPAFSSTYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCV 192

  Fly   176 SFRIATQTTVGTDV----KKDASFKNDSVLKSYETFMKIIVMNVLLPF--THNKIFSTLGGFETQ 234
            :..:..:...|.|:    :||:.|:|     :.|..:|.::::|..||  ...|.:..:......
Zfish   193 TLDVICKVAFGVDLNLLNQKDSPFQN-----AVELCLKGMILDVRDPFFRLFPKNWKLIQQVREA 252

  Fly   235 KALAKSNVNKMIGTIVDKKLMTKPESGSQPEITSVINKAIELHRNGEMSREEVQSECCSFVVAAF 299
            ..|.:....|.|..  .|..:...|...:..:|.::..|.|.:.|.....|::.....:|.:|..
Zfish   253 TELLRKTGEKWIQN--RKTAVKNGEDVPKDILTQILKSAEEENVNNTQDLEQMLDNFVTFFIAGQ 315

  Fly   300 ETTGDTVYHALILLAMFPEHQDTVYQELK-ELFPVAG-DFEVTYDDLQRMVFLERVVNETLRLIP 362
            |||.:.:..|::.|...||    :|:..| |:..|.| ..|::.:||.::.:|.:|:.|||||.|
Zfish   316 ETTANQLSFAIMALGRNPE----IYKRAKAEVDEVLGTKREISNEDLGKLTYLSQVLKETLRLYP 376

  Fly   363 SVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNVRDRHP-Y 426
            :.|.|.|....|. :.:|:.:|:|..:....:.:.| .:.:..||..|:|:.|   :|....| |
Zfish   377 TAPGTNRWLHEDI-VINGIKVPRGCSVMFSSYVSQR-LEKFFKDPLKFDPERF---DVNAPKPYY 436

  Fly   427 AYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCKVS----TSFRYED 469
            .|.|||.|.|.|:|..:..|.:||.|:|:|:..:.|    .||..:|
Zfish   437 CYYPFSLGPRTCLGQVFAQMEAKLVLAKLLQRFEFSLVPGQSFDIKD 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	110/460 (24%)
cyp46a1.1	NP_001018358.1	p450	39..495	CDD:278495	113/468 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010