DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a3 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	138/519 - (26%)
Similarity:	234/519 - (45%)	Gaps:	66/519 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAVGVCFWIYF-LWSRRRLYMMHFKIPGPMGLPILGIAFEYLITYKRKMSIRTKYMDIYG-STCL 70
            ||:.:....|| |...||..|:: |..||..||::|.|.:...|....::....:...|| ....
  Fly     9 LALPLFLVTYFELGLLRRKRMLN-KFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKDNFR 72

  Fly    71 VWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSKPVNSCTGDGLLSLEASKWVDRRKNLNPAFK 135
            .|:|....::..:||..|.|..|...:::|.::.. .:...|.|||:...|||...||.:.|||.
  Fly    73 YWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDL-THPWLGLGLLTSTGSKWHKHRKMITPAFH 136

  Fly   136 QNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDIVRWSFR---------IATQTTVGTDVKK 191
            .|:|..|..:.|..:   ..|:|.|     |||.|....:.|:         :...|.:|..:..
  Fly   137 FNILQDFHEVMNENS---TKFIDQL-----KKVADGGNIFDFQEEAHYLTLDVICDTAMGVSINA 193

  Fly   192 DASFKNDSVLKSYETFMKIIVMNVLLPFTHNK-IFSTLGGF-ETQKALAKSNVNKMIGTIVDKKL 254
            ..: ::.||:::::.....|.|....|:..|| :|.....: |..|.|  ..:......|:.|::
  Fly   194 MEN-RSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTL--KTLQDFTNEIIAKRI 255

  Fly   255 MTKPESGSQPEITSVINKAIELHR--------------NGE-MSREEVQSECCSFVVAAFETTGD 304
            ..: :||.:..|     ||.|..|              :|. ::.:|:..|..:|:....:||..
  Fly   256 EVR-KSGLEVGI-----KADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTS 314

  Fly   305 TVYHALILLAMFPEHQDTVYQELKELFPVAG-DFEVTYDDLQRMVFLERVVNETLRLIPSVPFTP 368
            .|..|:.||:..|:.|:.::.|..::...:| ..:.|:.::..|..|:..:.|..||.|||||..
  Fly   315 GVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIG 379

  Fly   369 RETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNVRDRH---PYAYIP 430
            |.|.:|: :..|.::|||..:.:.:.....| |....||..|.|:.|      ||.   |:.|:|
  Fly   380 RFTEKDY-VIDGDIVPKGTTLNLGLLMLGYN-DRVFKDPHKFQPERF------DREKPGPFEYVP 436

  Fly   431 FSKGRRNCIGWKYGLMSSKLALSKILRNCKVSTSFRYEDLEFVD-----NIGMELAQSPGLEFH 489
            ||.|.|||||.|:.|:..|..:|||:||.:|..:.  ::|...|     .:|::.|:....:.|
  Fly   437 FSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPAL--DELVSKDGYISTTLGLQPAEKKSRDAH 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	124/460 (27%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	124/460 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860