DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a3 and Cyp4d20

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	141/534 - (26%)
Similarity:	228/534 - (42%)	Gaps:	88/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGVCFWIYFLW--SRRRLYMMHFK---IPGPMGLPILG-------IAFEYLITYKRKMSIR 58
            |.|..|... :...|  .|:|..::.|:   ||||:.:||||       :..|.:|.:     :.
  Fly     3 LTLITGALI-LLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGW-----VG 61

  Fly    59 TKYMDIYGSTCLVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFS--KPVNSCTGDGLLSLEAS 121
            .|: |.||.|...|:.....:.|:|.:..|.|..|...|.:..::.  :|.   ..||||.....
  Fly    62 EKF-DKYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPF---LNDGLLVSTGR 122

  Fly   122 KWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDIVRW----SFRIATQ 182
            ||..|||....||...||..::.|.:..:..:|   |:|....:.|...|::::    :..:.|:
  Fly   123 KWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMV---DNLRKVADGKTAVDMLKYVSLAALDVITE 184

  Fly   183 TTVGTDV--KKDASFKNDSVLKS---------------YETFMKIIVMNVLLPFTHNKIFSTLGG 230
            ..:|..|  :.|..|.....|||               |.....:..     |..|.::.|.:..
  Fly   185 AAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAA-----PLLHRQLLSDIRV 244

  Fly   231 FE--TQKALAKSNVN----KMIGTIVDKKLMTKPESGSQPEITSVINKAI------ELHRNGEMS 283
            ..  |.|.:::....    |..||.       :|.|....||.|....|:      ....|..:|
  Fly   245 MHDFTDKVISERRETVRRAKADGTY-------RPLSLGDAEIGSKSQMALLDILLQSSINNQPLS 302

  Fly   284 REEVQSECCSFVVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGDFEVTYDDLQRMV 348
            ..:::.|..:|:....:||...|.|||..:|..||.|..:::||:.:........||...||.:.
  Fly   303 DADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLK 367

  Fly   349 FLERVVNETLRLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPD 413
            :|:.|:.||:||.|.||...|...::..:.. ..||....|.:.::..||:.::: .||.||.|:
  Fly   368 YLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYF-PDPLSFRPE 430

  Fly   414 HFLPDNVRDRHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCKVSTSFRYEDLEFVDNIGM 478
            .||.|..:..:.:||:|||.|.:||||.|:.::..|:.:||:||        .||.|.    :|.
  Fly   431 RFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLR--------FYELLP----LGE 483

  Fly   479 ELAQSPGLEFHRRT 492
            ||  .|.|.|..|:
  Fly   484 EL--KPMLNFILRS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	123/471 (26%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	132/498 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860