DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a3 and Cyp4ac1

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_608916.1	Gene:	Cyp4ac1 / 33754	FlyBaseID:	FBgn0031693	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	131/473 - (27%)
Similarity:	236/473 - (49%)	Gaps:	28/473 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IPGPM----GLPILGIAFEYLITYKRKMSIRTKYMDIYGSTCLVWVGPTPFVITRDPKIAEEIFL 92
            :||..    .|.||......:..:.|:.:.:.|     |...|.:....|......|:.|||:|.
  Fly    50 MPGKTRFGNNLDILNFTPASVFNFVRESTAKAK-----GQNYLWYFLYAPMYNVVRPEEAEEVFQ 109

  Fly    93 SPECLNRSSIFSKPVNSCTGDGLLSLEASKWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFL 157
            |.:.:.::.:: :.:....|||||.....||..|||.|.|||..|||.|||.||..|.|..:..|
  Fly   110 STKLITKNVVY-ELIRPFLGDGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVL 173

  Fly   158 DSLVGQGEKKVRDDIVRWSFRIATQTTVGTDVKKDASFKNDSVLKSYETFMKIIVMNVLLPFT-H 221
            :..: ..|.::...|..::.....:|.:|  ||.|...:.:...|:.....::::..|..|.. :
  Fly   174 EKNL-DAELELNQVIPPFTLNNICETALG--VKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYY 235

  Fly   222 NKIFSTLGGFETQKALAKSN-VNKMIGTIVDKK--LMTKPESGSQPEI-----TSVINKAIELHR 278
            |..|...|.:  :|.|.... |:.....|:::|  ...:.:.|...|.     .::::..:....
  Fly   236 NWYFFVYGDY--RKHLQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEA 298

  Fly   279 NGEMSREEVQSECCSFVVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGDFEVTYDD 343
            :|::..:.:..|..:|:...::||...:...|::||:..:.|...|:|::.| |...| :::...
  Fly   299 DGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENL-PEDSD-DISMFQ 361

  Fly   344 LQRMVFLERVVNETLRLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPS 408
            ..::|:||.|:.|:||:.|||||..|:.:.: .:.:|:|:||...|.|.|:...|:..|: ..|.
  Fly   362 FNKLVYLECVIKESLRMFPSVPFIGRQCVEE-TVVNGMVMPKDTQISIHIYDIMRDPRHF-PKPD 424

  Fly   409 SFNPDHFLPDNVRDRHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCKVSTSFRYEDLEFV 473
            .|.||.|||:|..:|||:||:|||.|:|||||.|:.::..|:.|:.::||.|:..:.:.|||.|.
  Fly   425 LFQPDRFLPENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLEDLTFE 489

  Fly   474 DNIGMELAQSPGLEFHRR 491
            :.|.:...::..::..:|
  Fly   490 NGIVLRTQENIKVKLSKR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	125/442 (28%)
Cyp4ac1	NP_608916.1	p450	86..504	CDD:278495	122/427 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1949
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960