DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a3 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	137/492 - (27%)
Similarity:	220/492 - (44%)	Gaps:	77/492 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WSRRRLYMMHFKIPG-PMGLPILGIA----------FEYLITYKRKMSIRTKYMDIYGSTCLVWV 73
            |.:.|      .||. ....|::|.|          |:.:|.|..:.    :::.|    ..:|:
  Rat    44 WQQMR------PIPSVARAYPLVGHALFMKPNNTEFFQQIIQYTEEF----RHLPI----IKLWI 94

  Fly    74 GPTPFVITRDPKIAEEIFLSPECLNRSSIFSKPVNSCTGDGLLSLEASKWVDRRKNLNPAFKQNV 138
            ||.|.|.....:..|.|..|.:.:::|.:: |.:....|.|||:...|||..|||.|.|:|...:
  Rat    95 GPVPLVALYKAENVEVILTSSKQIDKSFMY-KFLQPWLGLGLLTSTGSKWRARRKMLTPSFHFTI 158

  Fly   139 LLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDIVRWSFRIATQTTVGTDVKKDASFKNDSVLKS 203
            |..||.:.|.:|..||..|:..|.|........|...:..|..:|.:|.::...::..::.|...
  Rat   159 LEDFLDVMNEQANILVNKLEKHVNQEAFNCFFPITLCALDIICETAMGKNIGAQSNGDSEYVRTV 223

  Fly   204 YETFMKIIVMNVLLPF--------------THNKIFSTLGGFETQKALAKSNVNK----MIGTIV 250
            |. ...:|...:.:|:              .|.|...:|..|.......:.|..|    .||
  Rat   224 YR-MSDMIYRRMKMPWFWFDLWYLMFKEGRDHKKGLKSLHTFTNNVIAERVNARKAEQDCIG--- 284

  Fly   251 DKKLMTKPESGSQPEITSVINKA-IEL------HRNGEMSREEVQSECCSFVVAAFETTGDTVYH 308
                     :|..|..:....|| ::|      ....::|.|:::.|..:|:....:||...:..
  Rat   285 ---------AGRGPLPSKTKRKAFLDLLLSVTDEEGNKLSHEDIREEVDTFMFEGHDTTAAAINW 340

  Fly   309 ALILLAMFPEHQDTVYQELKELF-----PVAGDFEVTYDDLQRMVFLERVVNETLRLIPSVPFTP 368
            :|.||...||.|..|.:||.::|     |      ||.:||:::.:|:.|:.||||:.||||...
  Rat   341 SLYLLGSNPEVQRKVDKELDDVFGRSHRP------VTLEDLKKLKYLDCVIKETLRVFPSVPLFA 399

  Fly   369 RETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNVRDRHPYAYIPFSK 433
            |....|..: :|..|.||....|..:|.||:..:: .||..|.|:.|.|:|.:.||||||:|||.
  Rat   400 RSLSEDCEV-AGYKISKGTEAVIIPYALHRDPRYF-PDPEEFQPERFFPENSQGRHPYAYVPFSA 462

  Fly   434 GRRNCIGWKYGLMSSKLALSKILRNCKVSTSFRYEDL 470
            |.|||||.|:.:|..|..|:.|||...:.::.:.|:|
  Rat   463 GPRNCIGQKFAVMEEKTILACILREFWIESNQKREEL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	132/470 (28%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	129/454 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810