DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a3 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	114/491 - (23%)
Similarity:	200/491 - (40%)	Gaps:	78/491 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TFQLLLAVGVCFWIYFLWSRRRLYMMHFKIPGPMGLPILGIAFEYLITYKRKMSIRTKYMDI--- 64
            |..|||.....|:::..|..|...    :.|.|..        .:...:|....:..::.||
  Rat    26 TVLLLLFKTAQFYLHRRWLLRATQ----QFPSPPS--------HWFFGHKLSFLVDQEFQDILTR 78

  Fly    65 ---YGSTCLVWV-GPTPFVITRDPKIAEEI-------------FLSPECLNRSSIFSKPVNSCTG 112
               :.|.|..|: |....:...||...:.|             ||:|               ..|
  Rat    79 VKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRSDPKSHHSYRFLAP---------------WIG 128

  Fly   113 DGLLSLEASKWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDIVRWSF 177
            .|||.|....|...|:.|.|||..:.|..::.|.....:.::...:.:|||       |.....|
  Rat   129 YGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQ-------DSTLEIF 186

  Fly   178 RIATQTTVGTDVK----KDASFKNDSVLKSY----ETFMKIIVMNVLLPFTHNKIFSTL--GGFE 232
            :..|..|:.|.:|    ::.|.:.|...|||    |....:....:...|..|.|..:|  .|.:
  Rat   187 QHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRK 251

  Fly   233 TQKA--LAKSNVNKMI----GTIVDKKLMTKPESGSQPEITSVINKAIELHRNGEMSREEVQSEC 291
            .:.|  ||..:.:::|    ..:.|::.:.|.:...:.:...::..| .:.....:|.:::::|.
  Rat   252 ARSAWQLAHEHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFA-RIENGSSLSDKDLRAEV 315

  Fly   292 CSFVVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGD-FEVTYDDLQRMVFLERVVN 355
            .:|:....:||...:......||..||||....:|::.|.   || ..:|:|||.:|.:....:.
  Rat   316 DTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLL---GDGASITWDDLDKMPYTTMCIK 377

  Fly   356 ETLRLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNV 420
            |.||:.|.|....|..........|..:|||:.:.:..:..|.|...| .:|..|:|..|.|::
  Rat   378 EALRIYPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVW-PNPEVFDPYRFAPES- 440

  Fly   421 RDRHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKIL 456
             .||.::::|||.|.|||||.::.:...|:|::..|
  Rat   441 -SRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	107/461 (23%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	104/433 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900