DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a3 and CYP4A11

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens

Alignment Length:	526	Identity:	121/526 - (23%)
Similarity:	212/526 - (40%)	Gaps:	110/526 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGVCFWIYFLWSRRRLYMMHFKIPGPMGLPILGIAFEYLITYKRKMSIRTKYMDIYGSTCL 70
            |||...|..:::..|..:.|.    :.|.|....:.|...|  :...:::....|:::.:.|.|.
Human    29 LLLIKAVQLYLHRQWLLKALQ----QFPCPPSHWLFGHIQE--LQQDQELQRIQKWVETFPSACP 87

  Fly    71 VWV-GPTPFVITRDPKIAEEI-------------FLSPECLNRSSIFSKPVNSCTGDGLLSLEAS 121
            .|: |....|...||...:.|             ||:|               ..|.|||.|...
Human    88 HWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAP---------------WIGYGLLLLNGQ 137

  Fly   122 KWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEK---------KVRDDIVRWSF 177
            .|...|:.|.|||..::|..::.:.....:.::...:.|:||...         ...|.|::.:|
Human   138 TWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAF 202

  Fly   178 RIATQTTVGTDVKKDASFKNDSVLKSYETFMKIIVMNVLLPFTHN-KIFS-TLGGFETQKA--LA 238
              :.|.::..|      ..:.|.:::......::...|...|..| .|:| |..|..|.:|  ||
Human   203 --SHQGSIQVD------RNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLA 259

  Fly   239 KSNVNKMI----------GTI-----------VDKKLMTKPESGSQPEITSVINKAIELHRNGEM 282
            ..:.:::|          |.:           :|..|:.|.|:||                  .:
Human   260 HQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGS------------------IL 306

  Fly   283 SREEVQSECCSFVVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGD-FEVTYDDLQR 346
            |.:::::|..:|:....:||...:...|..||..|:||:...:|:..|.   || ..:|::.|.:
Human   307 SDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL---GDGASITWNHLDQ 368

  Fly   347 MVFLERVVNETLRLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFN 411
            |.:....:.|.|||.|.||...||.........|..:|||:.:.:.|:..|.|...| .:|..|:
Human   369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVW-PNPEVFD 432

  Fly   412 PDHFLPDNVRDRHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCKVSTSFRYEDLEFVDNI 476
            |..|.|.:.  :|.:|::|||.|.|||||.::.:...|:|.:        .|..|:|.|.....|
Human   433 PFRFAPGSA--QHSHAFLPFSGGSRNCIGKQFAMNELKVATA--------LTLLRFELLPDPTRI 487

  Fly   477 GMELAQ 482
            .:.:|:
Human   488 PIPIAR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	109/478 (23%)
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	115/499 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810