Protein Alignment Cyp313a3 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_650170.2
• Gene: Cyp313a3 / 41488
• FlyBaseID: FBgn0038007
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 141/523 - (26%)
• Similarity: 220/523 - (42%)
• Gaps: 91/523 - (17%)

  Fly     6 LLLAVGVCFWIYFLWSRRRLYMMHFKIPGPMGLPILGIAFEYLITYKRK------MSIRTKYMDI 64
            |||||.:.. :|...:|.........||||..||.||.|..:     ||      |....||..:
Human    13 LLLAVSLIL-LYLYGTRTHGLFKKLGIPGPTPLPFLGNALSF-----RKGYWTFDMECYKKYRKV 71

  Fly    65 YGSTCLVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSK-----PVNSCTGDGLLSLEASKWV 124
            :|    ::....|.:...||.:.:.: |..||.   |:|:.     ||.... :.:...|..:|.
Human    72 WG----IYDCQQPMLAITDPDMIKTV-LVKECY---SVFTNRRPFGPVGFMK-NAISIAEDEEWK 127

  Fly   125 DRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDIV-RWSFRIATQTTVGTD 188
            ..|..|:|.|....|...:||.......||..|......|:......:. .:|..:.|.|:.|..
Human   128 RIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192

  Fly   189 VKKDASFKNDSVLKSYETFM----KIIVMNVLLPFTHN-KIFSTLGGFETQKALAKSNVNKMIGT 248
            :        ||:....:.|:    |::..|.|.||..: |:|..|     ...|...|:     |
Human   193 I--------DSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFL-----TPILEALNI-----T 239

  Fly   249 IVDKKL---MTKP----ESGSQPE------------ITSVINKAIELHRNGEMSREEVQSECCSF 294
            :..:|:   :||.    :.|...|            |.|..:|..|.|:  .:|..|:.::...|
Human   240 VFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHK--ALSDLELMAQSIIF 302

  Fly   295 VVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGDFEVTYDDLQRMVFLERVVNETLR 359
            :.|.:|||...:...:..||..|:.|..|.:|:..:.|  .....|||.:.::.:|:.|||||||
Human   303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLP--NKAPPTYDTVLQLEYLDMVVNETLR 365

  Fly   360 LIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNVRDRH 424
            |.|......|...:|..: :|:.|||||.:.|..:..|.:..:| |:|..|.|:.|...|..:..
Human   366 LFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYW-TEPEKFLPERFSKKNKDNID 428

  Fly   425 PYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRN-----CK---VSTSFRYEDLEFVDNIGMELA 481
            ||.|.||..|.|||||.::.|::.||||.::|:|     ||   :....|:.        |:.|.
Human   429 PYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG--------GLLLT 485

  Fly   482 QSP 484
            :.|
Human   486 EKP 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	CYP313-like	66..487	CDD:410680	120/457 (26%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	122/463 (26%)