DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a3 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	487	Identity:	122/487 - (25%)
Similarity:	209/487 - (42%)	Gaps:	71/487 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGVCFWIYFLWSRRRLYMMHFKIPGPMGLPILGIAFEY--------LITYKRKMSIRTKYM 62
            ::|.|.|...:..|:.|::|.......|||....:.|.|.|.        ::|:..:..
Mouse    20 VILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALEIQKTGGLDKVVTWTEQFP------ 78

  Fly    63 DIYGSTCLVWVGP-TPFVITRDPKIAEEIFL--SPECLNRSSIFSKPVNSCTGDGLLSLEASKWV 124
              |...  :|:|. ..|:...:|..|:.::.  .|:.......|.:.:    |.|||.||..||.
Mouse    79 --YAHP--LWLGQFIVFLNIYEPDYAKAVYSRGDPKAAYVYDFFLQWI----GKGLLVLEGPKWF 135

  Fly   125 DRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRD--------DIVRWSFRIAT 181
            ..||.|.|.|..:||..::.||   |::....||    :.|||..:        |:...:.....
Mouse   136 QHRKLLTPGFHYDVLKPYVAIF---AESTRVMLD----KWEKKASENKSFDIFCDVGHMALDTLM 193

  Fly   182 QTTVGTDVKKDASFKNDSVLKSYETFMKIIVMNVLLPFT--------HNKI--FSTLGGFETQKA 236
            :.|.|         |.||.|...:....:.|.::.|...        ||..  :.|..|....:|
Mouse   194 KCTFG---------KGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRA 249

  Fly   237 --LAKSNVNKMI----GTIVDKKLMTKPESGSQPEITSVINKAIELHRNG-EMSREEVQSECCSF 294
              :|..:.:.:|    ..:.|:|...|.:.....:...::..|.:  .:| ::|..::::|..:|
Mouse   250 CQIAHDHTDHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGARD--ESGIKLSDADLRAEVDTF 312

  Fly   295 VVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGDFEVTYDDLQRMVFLERVVNETLR 359
            :....:||...:...|..:|::|.||....:|::|:......|:  :|||.:|.:|...:.|..|
Mouse   313 MFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQ--WDDLAQMTYLTMCMKECFR 375

  Fly   360 LIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNVRDRH 424
            |.|.||...|:..:......|..:|.|..|.:.|:|.|||...| .||..|:|..|.|:|:..||
Mouse   376 LYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVW-PDPEVFDPLRFSPENMTGRH 439

  Fly   425 PYAYIPFSKGRRNCIGWKYGLMSSKLALSKIL 456
            |:|::|||.|.|||||.::.:...|:..:..|
Mouse   440 PFAFMPFSAGPRNCIGQQFAMNEMKVVTALCL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	116/460 (25%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	116/460 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810