DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a3 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_031837.2	Gene:	Cyp26a1 / 13082	MGIID:	1096359	Length:	497	Species:	Mus musculus

Alignment Length:	466	Identity:	113/466 - (24%)
Similarity:	209/466 - (44%)	Gaps:	33/466 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGVCFW-IYFLWSRRRLYMMHFKIPGPMGLPILGIAFEYLITYKRKMSI-RTKYMDIYGST 68
            ||....:..| :|.:.||.|...:... ||.||.|..|...:.::..::.:.: |.||..||.:.
Mouse    19 LLFLAALKLWDLYCVSSRDRSCALPLP-PGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTH 82

  Fly    69 CLVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSKPVNSCTGDGLLS-LEASKWVDRRKNLNP 132
              ::..||..|:..|.  ...|.|....| .|..:...|.:..|.|.|| |..|....|:|.:..
Mouse    83 --LFGRPTVRVMGADN--VRRILLGEHRL-VSVHWPASVRTILGAGCLSNLHDSSHKQRKKVIMQ 142

  Fly   133 AFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEK--KVRDDIVRWSFRIATQTTVGTDVKKDASF 195
            ||.:..|..::|:...|..:.   |:..:..||:  .|..::.|..||||.:..:|.:.......
Mouse   143 AFSREALQCYVPVIAEEVSSC---LEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGPAGGG 204

  Fly   196 KND-SVLKSYETFMK-IIVMNVLLPFTHNKIFSTLGGFETQKA--LAKSNVNKMIGTIVDKKLMT 256
            ::: .:::::|...: :..:.:.:||:        |.:...||  |..:.:.:.|...:.:...|
Mouse   205 EDEQQLVEAFEEMTRNLFSLPIDVPFS--------GLYRGVKARNLIHARIEENIRAKIRRLQAT 261

  Fly   257 KPESGSQPEITSVINKAIELHRNGEMSREEVQSECCSFVVAAFETTGDTVYHALILLAMFPEHQD 321
            :|:.|.:..:..:|..:.|  |...:..:.::......:....|||.......:..|.::|....
Mouse   262 EPDGGCKDALQLLIEHSWE--RGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQ 324

  Fly   322 TVYQELKE---LFPVAGDFEVTYDDLQRMVFLERVVNETLRLIPSVPFTPRETIRDFRLSSGVVI 383
            .|.:|:|.   |.....|.::..:.|:::.:...|:.|||||.|.||...|..::.|.| :|..|
Mouse   325 KVREEIKSKGLLCKSNQDNKLDMETLEQLKYTGCVIKETLRLNPPVPGGFRVALKTFEL-NGYQI 388

  Fly   384 PKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNVRDRHPYAYIPFSKGRRNCIGWKYGLMSS 448
            |||..:...|..||...|.: |:...||||.|:..:..|...:::|||..|.|:|:|.::..:..
Mouse   389 PKGWNVIYSICDTHDVADIF-TNKEEFNPDRFIVPHPEDASRFSFIPFGGGLRSCVGKEFAKILL 452

  Fly   449 KLALSKILRNC 459
            |:...::.|:|
Mouse   453 KIFTVELARHC 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	106/438 (24%)
Cyp26a1	NP_031837.2	p450	43..491	CDD:299894	106/442 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4598
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.950