Protein Alignment Cyp313a3 and CYP46A1

DIOPT Version :9

• Sequence 1: NP_650170.2
• Gene: Cyp313a3 / 41488
• FlyBaseID: FBgn0038007
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 116/482 - (24%)
• Similarity: 214/482 - (44%)
• Gaps: 67/482 - (13%)

  Fly     6 LLLAVGVCFWIYFLWSRRRLYMMHFKIPGPMGLPILGIAFEYLITYKRKMSIRTKYM-DI----- 64
            :|||.|:|  ..|:...|..|.   .||||   |.......:|..:.:|..:..:.: |:
Human    12 VLLAFGLC--CTFVHRARSRYE---HIPGP---PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWA 68

  Fly    65 --YGSTCLVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSKPVNSCTGD-----GLLS-LEAS 121
              ||....|.|.....||...|:..::..:|.: .|:.|...:.:.:..|:     ||:| ....
Human    69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTK-YNKDSKMYRALQTVFGERLFGQGLVSECNYE 132

  Fly   122 KWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLV-GQGEKKVRDDIVRWSFRIATQTTV 185
            :|..:|:.::.||.::.|:|.:..||.:|:.||..|::.. ||....::|.:          |..
Human   133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML----------TYT 187

  Fly   186 GTDVKKDASFKNDSVL-----KSYETFMKIIVMNVLLPFTHNKIFSTLGGFETQKALAKSNVN-- 243
            ..|:...|:|..::.:     |.....:|:::..:..  :.|.:...|.|...|....:.::.
Human   188 AMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITA--SRNTLAKFLPGKRKQLREVRESIRFL 250

  Fly   244 KMIGT--IVDKKLMTKPESGSQPEITSVINKAIELHRNGEMSREEVQSECCSFVVAAFETTGDTV 306
            :.:|.  :..::...|.......:|.:.|.||.|    |....|.:.....:|.:|..||:.:.:
Human   251 RQVGRDWVQRRREALKRGEEVPADILTQILKAEE----GAQDDEGLLDNFVTFFIAGHETSANHL 311

  Fly   307 YHALILLAMFPEHQDTVYQELKELFPVAGDFEVTYDDLQRMVFLERVVNETLRLIPSVPFTPR-- 369
            ...::.|:..||....:..|:.|:  :.....:.::||.|:.:|.:|:.|:|||.|....|.|
Human   312 AFTVMELSRQPEIVARLQAEVDEV--IGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL 374

  Fly   370 --ETIRDFRLSSGVVIPKGVGIGIDIFATH--RNRDHWGTDPSSFNPDHFLPDNVRDRHPYAYIP 430
              ||:.|     ||.:|....:   :|:|:  ...|.:..||.:||||.|.|...:.|  :.|.|
Human   375 EEETLID-----GVRVPGNTPL---LFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFP 429

  Fly   431 FSKGRRNCIGWKYGLMSSKLALSKILR 457
            ||.|.|:|||.::..|..|:.::|:|:
Human   430 FSLGHRSCIGQQFAQMEVKVVMAKLLQ 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	107/455 (24%)
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	107/455 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920