DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	421	Identity:	107/421 - (25%)
Similarity:	189/421 - (44%)	Gaps:	45/421 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YMAWIG-TTPIVITRDPKIAEKVLTSPFCI-NRSSQTTNALALSMGYGLLTLQGSKWMARRKHMN 131
            :..|:| .:|::....|.|...|:.:...| .:.....:.|...:|.|||...|.||...|:.:.
Human    88 FKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLT 152

  Fly   132 PAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEK--DVLSDLIRWSFAIATQTTLGTDVTKDDN 194
            |||..::|..::.|||...:::.:.:.....:|..  |:...:     ::.|..:|...|...|:
Human   153 PAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHI-----SLMTLDSLQKCVFSFDS 212

  Fly   195 FENDAILKTYQSMLRLTIINIFVPFVQNKIVSK-----LFGLEWLR---------RRDASAINKM 245
            ...:...:...::|.|           :.:|||     |..:::|.         ||....::..
Human   213 HCQEKPSEYIAAILEL-----------SALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDF 266

  Fly   246 INNILDKKLNSNPEN------YCESELKTVIHRAIELFRNDE----MSLMELGAECSSMVLAAFE 300
            .:.::.::..:.|..      ..:::.||:....:.|...||    :|..::.||..:.:....:
Human   267 TDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHD 331

  Fly   301 TSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNETLRLMPSVP 365
            |:|..:.:.|..||..||:||....|::|.....:..|:...||..|.:|...:.|:|||.|.||
Human   332 TTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVP 396

  Fly   366 FSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHDRHPYAFIP 430
            ..||...:|:.|.:|.|||||:...|.:|.|..|...| .:...::|..|.||.|.:|.|.||||
Human   397 VISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-PDPEVYDPFRFDPENIKERSPLAFIP 460

  Fly   431 FSKGKRNCIGWRYGLMSSKLALVKILRNYKL 461
            ||.|.|||||..:.:...|:.|...|..:::
Human   461 FSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	107/421 (25%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	107/421 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810