DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a2 and CYP721A1

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_177649.1	Gene:	CYP721A1 / 843850	AraportID:	AT1G75130	Length:	505	Species:	Arabidopsis thaliana

Alignment Length:	552	Identity:	130/552 - (23%)
Similarity:	225/552 - (40%)	Gaps:	112/552 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIVIQLLIAASLILWIRFLWSRRKLYMLMMQLPGRM-----GLPLLGNSVRYLIISRGRMSSRTT 60
            |.|..:|:.....|..||::|.       :.:|.|:     ...:.|.|.|....:.|.:|..|.
plant     1 MAVFFILVLVFFFLVFRFIYSN-------IWVPWRIQSHFKKQSVTGPSYRIFSGNSGEVSRLTA 58

  Fly    61 --------------------------YMDKHGSTYMAWIGTTPIVITRDPKIAEKVLTSPFCINR 99
                                      :...:|.|::.|.|:.|:|.|.||::..:.||:....:|
plant    59 EAKSKPIPSGRNPHEFVHRVAPHYHEWSRVYGKTFLYWFGSKPVVATSDPRLIREALTTGGSFDR 123

  Fly   100 SSQTTNALA-LSMGYGLLTLQGSKWMARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQ 163
            ...  |.|: |....||..|:|.:|...|:....||....|..::|.....|.:|:..::.....
plant   124 IGH--NPLSKLLYAQGLPGLRGDQWAFHRRIAKQAFTMEKLKRWVPQMVTSTMMLMEKWEDMRNG 186

  Fly   164 GEK---DVLSDLIRWSFAIATQTTLGTDVTKDDNFENDAILKTYQSMLRLTII---NIFVP---F 219
            ||:   :|..::...|..:.::|..|..|.     |...|.:..:.|:||..:   ::::|   |
plant   187 GEEIELEVHKEMHNLSAEMLSRTAFGNSVE-----EGKGIFELQERMMRLFYLVRWSVYIPGFRF 246

  Fly   220 VQNKIVSKLFGLEWLRRRDASAINKMINNILDKKLNSNPENYCESELKTVIHRA---IELF---- 277
            ..:|           ..|:...|.|.|...:.|.:.:|         ||.:.::   ::.|
plant   247 FPSK-----------TNREIWRIEKQIRVSILKLIENN---------KTAVEKSGTLLQAFMSPY 291

  Fly   278 -----RNDEMSLMELGAECSSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEI-----KEHFP 332
                 :.:::.:.|:..||.:...||.||:|:.:.:.||||||..|.|.:...|:     :...|
plant   292 TNQNGQEEKLGIEEVTDECKTFYFAAKETTANLMTFVLVLLAMNQEWQNIAREEVICVLGQTGLP 356

  Fly   333 LAKGIEVTHTDLQQLVYLDRVLNETLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQ 397
                   |...||.|..|..::||||||.|.....:|:||:..:|.: :.||.|..:.:.:....
plant   357 -------TLDILQDLKTLSMIINETLRLYPPAMTLNRDTLKRAKLGD-LDIPAGTQLYLSVVAMH 413

  Fly   398 RNTDYWGSEAAQFNPENFLPEKIHDRHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKLK 462
            .:.:.||.:|.:|||..|...|   :.....:||..|.|.|:|....:..:|..|..||:.|..:
plant   414 HDKETWGDDAEEFNPRRFEDPK---KQSALLVPFGLGPRTCVGQNLAVNEAKTVLATILKYYSFR 475

  Fly   463 TSFPYENLEFVDHMVIKLAQSPQ----LAFER 490
            .|..|.:..     |:.:...||    |.|.|
plant   476 LSPSYAHAP-----VLFVTLQPQNGAHLLFTR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	115/487 (24%)
CYP721A1	NP_177649.1	p450	26..495	CDD:386267	120/511 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	169	1.000	Domainoid score	I1170
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.060