DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	XP_006524820.1	Gene:	Cyp4f40 / 631304	MGIID:	3645508	Length:	551	Species:	Mus musculus

Alignment Length:	498	Identity:	130/498 - (26%)
Similarity:	209/498 - (41%)	Gaps:	82/498 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILWI--RFLWSRRKLYMLMMQLPGRMGLPL----------LGNSVRYLIISRGRMSSRTTYMDKH 65
            |.|.  |||   .:||.|..:.....|.|.          ||.|..    :...|...|..:..:
Mouse    54 ISWFLARFL---TQLYTLYAKCQRLCGFPQPPKKNWFWGHLGMSPP----TEEGMKQVTELVTTY 111

  Fly    66 GSTYMAWIG-TTPIVITRDPKIAEKVLTSPFCI-NRSSQTTNALALSMGYGLLTLQGSKWMARRK 128
            ...:|.|:| ..|::....|.|...||::...: .:.....:.|...:|.|||...|.||...|:
Mouse   112 PQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDDIFYSFLKPWLGDGLLVSAGDKWNRHRR 176

  Fly   129 HMNPAFKHSVLLSFLPIFNAETDLL--------------VSVFDSFVGQGEKDVLSDLIRWSF-- 177
            .:.|||..::|..::.|||..|:::              :::|:: :.....|.|...: :||
Mouse   177 MLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGGSTRLNMFEN-ISLMTLDTLQKCV-FSFNS 239

  Fly   178 --------AIATQTTLGTDVTKDDNFENDAILKTYQSMLRLT-----------IINIFVPFVQNK 223
                    .||....|.|...|    .|:.:|.....:.|||           :::.|...|
Mouse   240 NCQEKPSQYIAAILELSTLAVK----RNEQLLMHVDLLYRLTPDGMRFYKACRLVHDFTDAV--- 297

  Fly   224 IVSKLFGLEWLRRRDASAINKMINNILDKKLNSNPENYCESELKTVIHRAIELFRNDEMSLMELG 288
                      ::.|..:.:....::|:..|..|...::.:..|.|......||  :||    ::.
Mouse   298 ----------IQERRRTLLKHGGDDIIKAKAKSKTLDFIDVLLLTKDEDGKEL--SDE----DIR 346

  Fly   289 AECSSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRV 353
            ||..:.:....:|:|..:.:.|..||..|||||....|::|........|:...||.||.:|...
Mouse   347 AEADTFMFRGHDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEIEWDDLAQLPFLTMC 411

  Fly   354 LNETLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPE 418
            :.|:|||.|.|...||...:|:.|.:|.:||||:...|:||.|..|...| .:...::|..|.||
Mouse   412 IKESLRLHPPVTMVSRCCTQDISLPDGRIIPKGVICIINIFGTHHNPTVW-RDPEVYDPFRFDPE 475

  Fly   419 KIHDRHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKL 461
            .|..|.|.:|||||.|.|||||..:.:...|:||...|..:::
Mouse   476 NIQARSPLSFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRI 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	122/476 (26%)
Cyp4f40	XP_006524820.1	p450	79..542	CDD:365848	121/470 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810