DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	490	Identity:	121/490 - (24%)
Similarity:	212/490 - (43%)	Gaps:	49/490 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VIQLLIAASLIL-----WIRFLWSRRKLYMLMMQLP------GRMGLPLLGNSVRYLIISRGRMS 56
            ::.||:..|.:|     |....:...:......|.|      |..||         :..:...|.
Human    20 LLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGL---------VTPTEEGMK 75

  Fly    57 SRTTYMDKHGSTYMAWIGTT-PIVITRDPKIAEKVLTSPFCINRSSQT-TNALALSMGYGLLTLQ 119
            :.|..:..:...:..|:|.| |::|...|.|...:.::...:...... ...|...:|.|||...
Human    76 TLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSG 140

  Fly   120 GSKWMARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLIRWSFAIATQTT 184
            |.||...|:.:.|||..::|..::.|||...:::...:.....:|...:  |:.. ..::.|..:
Human   141 GDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARL--DMFE-HISLMTLDS 202

  Fly   185 LGTDVTKDDNFENDAILKTYQSMLRLTIINIFVPFVQNKIVSKLFGLEWLR------RRDASAIN 243
            |...|.   :||::...|..:.:..:..::.||.....:|:.....|.:|.      ||....::
Human   203 LQKCVF---SFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVH 264

  Fly   244 KMINNILDKKLNSNP--------ENYCESELKTVIHRAIELFRND----EMSLMELGAECSSMVL 296
            ...:.::.::..:.|        :|..:|  ||:....:.|...|    |:|..::.||..:.:.
Human   265 DFTDAVIQERRCTLPTQGIDDFLKNKAKS--KTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMF 327

  Fly   297 AAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNETLRLM 361
            ...:|:|..:.:.|..||..||:||....|::|.....:.||:...||.||.:|...:.|:|||.
Human   328 EGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLH 392

  Fly   362 PSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHDRHPY 426
            |.||..||...:|..|.:|.|||||:...|:|.....|...| .:...::|..|..|.|.:|.|.
Human   393 PPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVW-PDPEVYDPFRFDQENIKERSPL 456

  Fly   427 AFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKL 461
            ||||||.|.|||||..:.:...|:.|...|.::::
Human   457 AFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	115/455 (25%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	116/458 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810