DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	525	Identity:	139/525 - (26%)
Similarity:	249/525 - (47%)	Gaps:	66/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAASLILWIRFLWSRRKLYM----LMMQLPGRMG-LPLLGNSVRYLI--------ISRGRMSS 57
            |..|..|:|.....::..|.|:    .|..:||..| .|::||::::..        |..|
Zfish    13 LFTAVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNAGDFFNQIIEG---- 73

  Fly    58 RTTYMDKHGSTYMAWIGTTPIVITRDPKIAEKVLTSPFCINRSSQTTNALALSMGYGLLTLQGSK 122
              |..::|......|:|..|.:|....:..|.||::...::: |.:...|...:|.||||..|.|
Zfish    74 --TNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDK-SYSYRFLHPWLGTGLLTSTGEK 135

  Fly   123 WMARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLIRWSFAIATQTTLGT 187
            |..|||.:.|.|..|:|..||.:.|.:||:|:............:..:.:...:..|..:|.:|.
Zfish   136 WRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCFNFITLCALDIICETAMGK 200

  Fly   188 DVTKDDNFENDAILKTYQSMLRLT-IIN-------IFVPFVQNKIVSKLFGLEWLRRRDASAINK 244
            .:....|.:::.:    ||:.::: ||.       ::..::.||:..   |.|..:|  ...::.
Zfish   201 KIYAQSNADSEYV----QSVYKMSDIITKRQRAPWLWPDWIYNKLKE---GKEHAKR--LKILHS 256

  Fly   245 MINNILDKK---LNSNPEN-----------YCESELKTVIHRAIELFRNDEMSLMELGAECSSMV 295
            ...|::.::   ::|.|::           :.:..|||......:|...|      :..|..:.:
Zfish   257 FTANVIRERAEFMSSEPDSDSDQGERKRQAFLDMLLKTTYENGQKLSHED------IQEEVDTFM 315

  Fly   296 LAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAK---GIEVTHTDLQQLVYLDRVLNET 357
            ....:|:|.::.:||.|:...||.|:.|..|::|.|..::   |:|    ||::|.||:.|:.|:
Zfish   316 FEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSERHVGVE----DLKKLRYLECVIKES 376

  Fly   358 LRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHD 422
            ||:.||||..:|...|...: ||..:|||:...|..:...|:..|: .|..:|.||.|:||....
Zfish   377 LRIFPSVPLFARSICEACHI-NGFKVPKGVNAVIIPYALHRDPRYF-PEPEEFQPERFMPENSKG 439

  Fly   423 RHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKLKTSFPYENLEFVDHMVIKLAQSPQLA 487
            |||||:||||.|.|||||.|:.:|..|:.|..|||::.::.....|.|..:..::::..:...:.
Zfish   440 RHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELRPLGELILRPEKGIWIK 504

  Fly   488 FERRT 492
            .:||:
Zfish   505 LQRRS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	128/463 (28%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	130/488 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910