DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and cyp26b1

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_997831.1	Gene:	cyp26b1 / 324188	ZFINID:	ZDB-GENE-030131-2908	Length:	511	Species:	Danio rerio

Alignment Length:	489	Identity:	125/489 - (25%)
Similarity:	215/489 - (43%)	Gaps:	59/489 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIVIQLLIAASLILW-IRFLWSRRKLYMLMMQLPGRMGLPLLGNSVRYLIISRGRMSSRTTYMDK 64
            ::.:.||:|.|..|| :|:..:|.|...|.|. .|.||.|::|.:..:.....|..:||   ..|
Zfish    19 LVSMALLLAVSQQLWQLRWTATRDKSCKLPMP-KGSMGFPIIGETCHWFFQGAGFHASR---RQK 79

  Fly    65 HGSTYMAWIGTTPIVITRDPKIAEKVLTSPFCI-----NRSSQT---TNALALSMGYGLLTLQGS 121
            :|:.:...:...|::.....:...|||.....:     .:|:.|   .|:||.|:        |.
Zfish    80 YGNVFKTHLLGRPLIRVTGAENVRKVLMGEHSLVTVDWPQSTSTLLGPNSLANSI--------GD 136

  Fly   122 KWMARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLIRWSFAIATQTTLG 186
            ....|||.....|.|..|.|:||.........:.|:.|  .....:|..:..|.||.:|.:..||
Zfish   137 IHRKRRKIFAKVFSHEALESYLPKIQQVIQETLRVWSS--NPDPINVYRESQRLSFNMAVRVLLG 199

  Fly   187 TDVTKDDNFENDAILKTYQSMLRLTIINIF-----VPFVQNKIVSKLFGLEWLRRRDASAINKMI 246
            ..:.::   |...:..|:|..:.    |:|     :||...:        :.:|.||  ::.|.|
Zfish   200 FRIPEE---EMHCLFSTFQEFVE----NVFSLPIDLPFSGYR--------KGIRARD--SLQKSI 247

  Fly   247 NN-ILDKKLNSNPENYCESELKTVIHRAIELFRNDEMSLMELGAECSSMVLAAFETSAHTVYYAL 310
            .. |.:|.|::..::|.:: |..::..|.|  .|.|:::.||......::.|||.|:|......:
Zfish   248 EKAIREKPLHTQGKDYTDA-LDVLLESAKE--NNTELTMQELKESTIELIFAAFATTASASTSLV 309

  Fly   311 VLLAMFPEHQEMVFNEIKEHFPLAKGI----EVTHTDLQQLVYLDRVLNETLRLMPSVPFSSRET 371
            :.|...|...|.:..|::....|..|.    |:....:..|.|||.|:.|.|||...|....|..
Zfish   310 MQLLRHPAVLEKLREELRSCGLLHDGCLCQGELRLDSIISLKYLDCVIKEVLRLFAPVSGGYRIA 374

  Fly   372 LEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHDRH-PYAFIPFSKGK 435
            .:...| :||.:|||.::...|.:| .:|.....:...|:|:.|.||:..||. .:.::||..|.
Zfish   375 TQTFEL-DGVQVPKGWSVMYSIRDT-HDTSAVFKDVEAFDPDRFSPERSEDREGRFHYLPFGGGV 437

  Fly   436 RNCIGWRYGLMSSKLALVKIL--RNYKLKT-SFP 466
            |:|:|.:...:..||..|::.  ..::|.| :||
Zfish   438 RSCLGKQLATLFLKLLAVELAGGSRFELSTRTFP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	111/450 (25%)
cyp26b1	NP_997831.1	p450	1..489	CDD:299894	125/489 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910