DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	549	Identity:	130/549 - (23%)
Similarity:	233/549 - (42%)	Gaps:	108/549 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VIQLL----------IAASLILWIRFLWSR----------------RKLYMLMMQLPGRMGLPLL 41
            ::|||          :.::|:|.:.|.:.|                ||| ....:.|||..  ||
Mouse     8 LLQLLGLEKTAFRVYVVSALLLLVLFFFFRLLVRAFKLFSDFRITCRKL-SCFPEPPGRHW--LL 69

  Fly    42 GNSVRYLIISRGRMSSRTTYMDKHGSTYMAWIGT-TPIVITRDPKIAEKVLTSPFCINRSSQ-TT 104
            |:...||...:| :.:....:|......:||:|. .|:::...|...:.||.:...|....: ..
Mouse    70 GHMSMYLPNEKG-LQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFY 133

  Fly   105 NALALSMGYGLLTLQGSKWMARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVL 169
            :.|...:|.|||..:|:||...|:.:.|||...:|..::.|||..|:::.:.:...:.:|
Mouse   134 SFLKPWLGDGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMHAKWRRHLAEG----- 193

  Fly   170 SDLIRWSFAIATQTTLGTDVTKDDNFENDAILKTYQSMLRL-----------------TIINIFV 217
                              .||..|.||:.::: |..|:.:.                 :||.:..
Mouse   194 ------------------SVTSFDMFEHISLM-TLDSLQKCVFSYNSDCQERMSDYISSIIELSA 239

  Fly   218 PFV--QNKIVSKLFGLEWLR------RRDASAINKMINNILDKKLNSNPENYCESELKTVIHRAI 274
            ..|  |.::...|..:.:|.      |:....::.....::.::..:..:...|:.||....:.:
Mouse   240 LVVRRQYRLHHYLDFMYYLTADGRRFRQACDTVHNFTTEVIQERRQALRQQGAEAWLKAKQGKTL 304

  Fly   275 E-----LFRND----EMSLMELGAECSSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEH 330
            :     |...|    |:|..::.||..:.:....:|::..:.:||..||.:||:||....||:|
Mouse   305 DFIDVLLLAKDEEGKELSDEDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQE- 368

  Fly   331 FPLAKGIEVTH---TDLQQLVYLDRVLNETLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISID 392
              :.||.|:..   .||.||.:....:.|:||..|.|...||...||::|.:|.|||||:...:.
Mouse   369 --VMKGRELEELDWDDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGRVIPKGIICLVS 431

  Fly   393 IFNTQRNTDYWGSEAAQFNPENFLPEKIHDRHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILR 457
            |:.|..|...| .::..:||..|.|:....|.|.||:|||.|.|||||..:.:...::.:...|.
Mouse   432 IYGTHHNPIVW-PDSKVYNPYRFDPDTPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLL 495

  Fly   458 NYKLKTSFPYENLEFVDHMVIKLAQSPQL 486
            .::|.....:           |:.:.|:|
Mouse   496 RFRLSVDRTH-----------KVRRKPEL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	117/468 (25%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	120/496 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810