DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	126/501 - (25%)
Similarity:	220/501 - (43%)	Gaps:	71/501 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VIQLLIAASLIL-------WIRFLWSRRKLYMLMMQLP---------GRMGLPLLGNSVRYLIIS 51
            ::.||:.||.:|       :..|..|||     :.:.|         |.:|  |:.:|...|:..
  Rat    20 LLLLLVGASCLLAYILPQVYAVFENSRR-----LRRFPQPPTRNWLFGHLG--LIQSSEEGLLYI 77

  Fly    52 RGRMSSRTTYMDKHGSTYMAWIGT-TPIVITRDPKIAEKVLTSPFCINRSSQT-TNALALSMGYG 114
            :   |...|:.|    ....|:|. .|::....|...:.|:.:|..:....:. ...|...:|.|
  Rat    78 Q---SLSRTFRD----VCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDG 135

  Fly   115 LLTLQGSKWMARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLIRWSFAI 179
            ||...|.||...|..:.|||..::|..::.|||..|:::.:.:.....||...:  |:.. ..::
  Rat   136 LLLSTGDKWSRHRHMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLASQGSARL--DMFE-HISL 197

  Fly   180 ATQTTLGTDV-TKDDNFEN------DAIL-------KTYQSMLRLTIINIFVPFVQNKIVSKLFG 230
            .|..:|...| :.|.|.:.      .|||       :.:||:  |..:::|....::       |
  Rat   198 MTLDSLQKCVFSFDSNCQEKPSEYITAILELSALVARRHQSL--LLYVDLFYHLTRD-------G 253

  Fly   231 LEWLRRRDASAINKMINNILDKKLNSNPEN------YCESELKTVIHRAIELFRNDE----MSLM 285
            :.:  |:....::...:.::.::..:.|:.      ..:::.||:....:.|...||    :|..
  Rat   254 MRF--RKACRLVHDFTDAVIRERRRTLPDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDE 316

  Fly   286 ELGAECSSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYL 350
            ::.||..:.:....:|:|..:.:.|..||..||:||....|::|.....:..|:...||.||.:|
  Rat   317 DIRAEADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFL 381

  Fly   351 DRVLNETLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENF 415
            ...:.|:|||.|.....||...:|:.|.:|.|||||:...|.||.|..|...| .:...:||..|
  Rat   382 TMCIKESLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVW-PDPEVYNPFRF 445

  Fly   416 LPEKIHDRHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKL 461
            ..:....|.|.||||||.|.|||||..:.:...|:||...|..:::
  Rat   446 DADNGEGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	117/464 (25%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	112/440 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810