Protein Alignment Cyp313a2 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_650169.3
• Gene: Cyp313a2 / 41487
• FlyBaseID: FBgn0038006
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 113/483 - (23%)
• Similarity: 200/483 - (41%)
• Gaps: 48/483 - (9%)

  Fly     1 MIVIQLLIAASLILWIRFLWSRRKLYMLMMQLPGRMGLPLLGNSVRYLIISRGRMSSRTTYMDKH 65
            ::::.||:..:..|::...|    |...:.|.|......|.|:      |...:.......:.:.
Human    24 LLILLLLLIKAAQLYLHRQW----LLKALQQFPCPPSHWLFGH------IQEFQHDQELQRIQER 78

  Fly    66 GST------YMAWIGTTPIVITRDPKIAEKVL--TSPFCINRSSQTTNALALSMGYGLLTLQGSK 122
            ..|      |..|.|...:.: .||...:.:|  :.|    :|..:...||..:|||||.|.|..
Human    79 VKTFPSACPYWIWGGKVRVQL-YDPDYMKVILGRSDP----KSHGSYKFLAPRIGYGLLLLNGQT 138

  Fly   123 WMARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLIRWSFAIATQTTLGT 187
            |...|:.:.|||.:.:|..::.:......:::..::..:||   |...::.:....:...|.:.:
Human   139 WFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQ---DSPLEVFQHVSLMTLDTIMKS 200

  Fly   188 DVTKDDNFENDAILKTYQSMLRLTIINIFV------PFVQNKIVSKLFGL-EWLRRRDASAINKM 245
            ..:...:.:.|...::|  :..::.:|..|      .|.:|..:..|... .|..|....|....
Human   201 AFSHQGSIQVDRNSQSY--IQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT 263

  Fly   246 INNILDKKLNSNPENYCESELKTVIH----RAIELFRNDEMSLM---ELGAECSSMVLAAFETSA 303
            ...|..:|.....|...| ::|...|    ..:.|.:.:..|::   :|.||..:.:....:|:|
Human   264 DQVIQLRKAQLQKEGELE-KIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTA 327

  Fly   304 HTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNETLRLMPSVPFSS 368
            ..:.:.|..||..|:|||....||  |..|..|..:|...|.|:.|....:.|.|||.|.||...
Human   328 SGISWILYALATHPKHQERCREEI--HGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIG 390

  Fly   369 RETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHDRHPYAFIPFSK 433
            ||....:...:|..:|||:.:.:.|:....|...| .....|:|..|.|...  :|.:||:|||.
Human   391 RELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVW-PNLEVFDPSRFAPGSA--QHSHAFLPFSG 452

  Fly   434 GKRNCIGWRYGLMSSKLALVKILRNYKL 461
            |.|||||.::.:...|:|....|..::|
Human   453 GSRNCIGKQFAMNQLKVARALTLLRFEL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	CYP313-like	66..487	CDD:410680	103/418 (25%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	103/425 (24%)