DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and Cyp26b1

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001171184.1	Gene:	Cyp26b1 / 232174	MGIID:	2176159	Length:	512	Species:	Mus musculus

Alignment Length:	526	Identity:	124/526 - (23%)
Similarity:	217/526 - (41%)	Gaps:	110/526 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIVIQLLIAASLILWIRFLWSRRKLYMLMMQLP-GRMGLPLLGNSVRYLIISRGRMSSRTTYMDK 64
            ::.:.||:|.|..|| :..|:..:.....:.:| |.||.||:|.:..:|:...|..|||   .:|
Mouse    19 LVSVTLLLAVSQQLW-QLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSR---REK 79

  Fly    65 HGSTYMA-------------------WIGTTPIVITRDPKIAEKVLTSPFCINRSSQTTNALALS 110
            :|:.:..                   .:|...:|.|..|:.| :||..|          |.:|.|
Mouse    80 YGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSA-RVLLGP----------NTVANS 133

  Fly   111 MGYGLLTLQGSKWMARRKHMNPAFKHSVLLSFLPIFNAETDLLV-SVFDSFVGQGEK-DVLSDLI 173
            :|    .:..:|    ||..:..|.|..|.|:||    :..|:: ....::..|.|. :|..:..
Mouse   134 IG----DIHRNK----RKVFSKIFSHEALESYLP----KIQLVIQDTLRAWSSQPEAINVYQEAQ 186

  Fly   174 RWSFAIATQTTLGTDVTKDDNFENDAILKTYQSMLRLTIINIF-----VPF------VQ-NKIVS 226
            |.:|.:|.:..||..:.::|   ...:.:.||..:.    |:|     :||      :| .:|:.
Mouse   187 RLTFRMAVRVLLGFSIPEED---LGHLFEVYQQFVE----NVFSLPVDLPFSGYRRGIQARQILQ 244

  Fly   227 KLFGLE-WLRRRDASAINKMINNILDKKLNSNPENYCESELKTVIHRAIELFRNDEMSLMELGAE 290
            |  ||| .:|.:......|..::.||..:.|:.|:                  ..||::.||...
Mouse   245 K--GLEKAIREKLQCTQGKDYSDALDILIESSKEH------------------GKEMTMQELKDG 289

  Fly   291 CSSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGI----------EVTHTDLQ 345
            ...::.||:.|:|......::.|...|...|.:..|::     |:|:          .:....|.
Mouse   290 TLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELR-----AQGLLHGGGCPCEGTLRLDTLS 349

  Fly   346 QLVYLDRVLNETLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQF 410
            .|.|||.|:.|.:||...|....|..|:...| :|..||||.::...|.:|......: .:...|
Mouse   350 SLRYLDCVIKEVMRLFTPVSGGYRTVLQTFEL-DGFQIPKGWSVMYSIRDTHDTAPVF-KDVNVF 412

  Fly   411 NPENFLPEKIHDRH-PYAFIPFSKGKRNCIGWRYGLMSSKLALVKI--LRNYKLKT-SFPYENLE 471
            :|:.|...:..|:. .:.::||..|.|.|:|.....:..|:..|::  ...::|.| :||...|.
Mouse   413 DPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLV 477

  Fly   472 FVDHMV 477
            .|.|.|
Mouse   478 PVLHPV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	110/477 (23%)
Cyp26b1	NP_001171184.1	CYP26B1	60..490	CDD:410730	111/484 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910