DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and Cyp4a29

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001093653.1	Gene:	Cyp4a29 / 230639	MGIID:	3717143	Length:	509	Species:	Mus musculus

Alignment Length:	507	Identity:	114/507 - (22%)
Similarity:	200/507 - (39%)	Gaps:	95/507 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IQLLIAASLIL--------WIRFLWSRRKLYMLMMQLPGRMGLPLLGNSVRYLIISRGRMSSRTT 60
            :|::....|:|        ::|..|..|.||    |.|......|.|:.:::.:....|...|
Mouse    19 LQVIFLIGLLLLLFKAAQHYLRRQWLLRALY----QFPSPPSHWLFGHCLQFKVDEELRWILR-- 77

  Fly    61 YMDKHGSTYMAWI-GTTPIVITRDPKIAEKVL--TSPFCINRSSQTTNALALSMGYGLLTLQGSK 122
            |::|....::.|| |:...:...||...:.:|  ..|     .:.....|...:|:||..|.|.:
Mouse    78 YLEKFPGAFLHWIWGSHVFIKVCDPDYMKVILGRADP-----KASLYRFLTPWLGHGLFFLNGDE 137

  Fly   123 WMARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDV------------LSDLIRW 175
            |...|:.:.|||.:.:|..::.|......:::..::....|   |:            |..::::
Mouse   138 WFQHRRLLTPAFHYDILKPYVGIMADSVQVMLEKWEQIACQ---DITLEIFHPISLMMLDTIMKY 199

  Fly   176 SFAIATQTTLGTDVTKDDNFENDAILKTYQSMLRLTIINIFVPFVQNKIVSKLFGLEWLRRRDAS 240
            :|:......|        :..:.|.|:....:..|....:...|:.|.|:   :.|....||..|
Mouse   200 AFSYQGSVQL--------DRSSQAYLQAVSDLNNLVTSRMKNVFLHNDII---YNLTSHSRRTNS 253

  Fly   241 AI--------------------NKMINNILDKKLNSNPENYCESELKTVIHRAIELFRNDEMSLM 285
            |.                    ||.:..:..|:        |...|..::     |.|.|:.|.:
Mouse   254 ACQIAHEHTDRVVKLRKAQLQDNKSMKKLRGKR--------CLDFLDILL-----LSRMDDGSSL 305

  Fly   286 E---LGAECSSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQL 347
            .   |.||..|::....:|.|..:.:....||..|:||:....|::.  .|..|..:|...|.|:
Mouse   306 SDKALRAEVDSLMFGGHDTPASGISWVFYALATHPDHQQRCREEVQS--LLGDGSPITWDHLHQM 368

  Fly   348 VYLDRVLNETLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNP 412
            .|....:.|.|||.|.:|...|:....:...:|..:|||:|:.:..:....|...|.      ||
Mouse   369 PYTTMCIKEALRLYPPIPSVGRKLSTPVTFPDGRSLPKGITVLLHFYALHHNPKVWP------NP 427

  Fly   413 ENFLPEKI---HDRHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKL 461
            |.|.|.:.   ..:|.:||:|||.|.|||||....:...|:|:...|..::|
Mouse   428 EVFDPSRFAMNSVQHSHAFLPFSGGSRNCIGKHLAMNVLKVAVALTLLRFEL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	105/470 (22%)
Cyp4a29	NP_001093653.1	p450	52..503	CDD:278495	105/470 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810