Protein Alignment Cyp313a2 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_650169.3
• Gene: Cyp313a2 / 41487
• FlyBaseID: FBgn0038006
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 117/549 - (21%)
• Similarity: 208/549 - (37%)
• Gaps: 132/549 - (24%)

  Fly     1 MIVIQLLIAASLILWIRFLWSRRKLYMLMMQLPGRM--------GLPLLGNSVRYLIISRGRMSS 57
            |::|......||:..||.....      ::|||..:        .:|.||:::.:   .:..:..
Human    35 MLLIACAFTLSLVYLIRLAAGH------LVQLPAGVKSPPYIFSPIPFLGHAIAF---GKSPIEF 90

  Fly    58 RTTYMDKH---------GSTYMAWIGTTPIVITRDPK----IAEKVLTSPFCINRSSQTTNALAL 109
            .....:|:         |.|:...:|:....:..:.|    .||.|.        |..||.....
Human    91 LENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVY--------SRLTTPVFGK 147

  Fly   110 SMGYGL---LTLQGSKWMARRKHMNPA-FKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLS 170
            .:.|.:   :.|:..|.:  :..:|.| ||..|     .|...||.   ..|:|:...|||:|..
Human   148 GVAYDVPNPVFLEQKKML--KSGLNIAHFKQHV-----SIIEKETK---EYFESWGESGEKNVFE 202

  Fly   171 DLIRWSFAIATQTTLGTDVTKDDNFENDAILKTYQSMLRLTIINIFVPFVQNKIVSKLFG----- 230
            .|.......|:....|.::               :|.|             |:.|::|:.
Human   203 ALSELIILTASHCLHGKEI---------------RSQL-------------NEKVAQLYADLDGG 239

  Fly   231 ---LEWL----------RRRDASAINKMINNILDKKLNSNPENYCESELKTVIHRAIEL------ 276
               ..||          ||||.:  ::.|.:|..|.:....::  :.::..::...::.
Human   240 FSHAAWLLPGWLPLPSFRRRDRA--HREIKDIFYKAIQKRRQS--QEKIDDILQTLLDATYKDGR 300

  Fly   277 -FRNDEMSLMELGAECSSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIK----EHFPLAKG 336
             ..:||::.|.:|     ::||...||:.|..:....||.....|:..:.|.|    |:.|
Human   301 PLTDDEVAGMLIG-----LLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLP---- 356

  Fly   337 IEVTHTDLQQLVYLDRVLNETLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTD 401
             .:|:..|:.|..|||.:.|||||.|.:....|.......:: |..||.|..:.:.....||..|
Human   357 -PLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGHQVCVSPTVNQRLKD 419

  Fly   402 YWGSEAAQFNPENFLPEKIHDRHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYK---LKT 463
            .| .|...|||:.:|.:.......:|::||..|:..|||..:..:..|.....:||.|:   :..
Human   420 SW-VERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 483

  Fly   464 SFPYENLEFVDHMVIKLAQSPQLAFERRT 492
            .||..|...:.|    ..::|.:.::||:
Human   484 YFPTVNYTTMIH----TPENPVIRYKRRS 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	CYP313-like	66..487	CDD:410680	102/460 (22%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	103/476 (22%)